A spatially unbiased atlas template of the human cerebellum
A spatially unbiased atlas template of the human cerebellum
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DOI：
10.1016/j.neuroimage.2006.05.056
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发表时间：
2006-10-15
期刊：
影响因子：
5.7
通讯作者：
Diedrichsen, Jorn
中科院分区：
文献类型：
--
作者：
Diedrichsen, Jorn
本文介绍了一种新的高分辨率图谱模板的人，小脑和脑干，解剖的基础上，20个年轻的健康人。该图谱是空间无偏的，即，每个结构的位置等于该结构在MNI空间中跨个体的预期位置，该结果用16个个体的独立样本交叉验证。同时，新模板通过非线性图谱生成算法保留了小脑结构的解剖细节。与目前的全脑模板相比，它可以改进功能性MRI和病变分析的逐体素标准化。与模板的比对要求小脑和脑干与周围组织分离，这是一个自动算法已经开发出来的过程。与MNI全脑模板的标准化相比，新方法大大改善了单个裂隙的对齐，将其空间分布减少了60%，并改善了小脑深部核的重叠。应用于功能性MRI数据，新的归一化技术导致运动与休息对比的小脑皮层的峰值t值和激活体积增加5-15%。这表明新模板显著改善了个体之间功能等同的小脑区域的重叠。模板和软件作为SPM工具箱可免费获得，该工具箱还允许用户将新模板与注释的体积（Schmahmann，J.D.，Doyon，J.，Toga，A.，Petrides，M.，埃文斯，A.（2000年）的第10/2000号决议。人类小脑的MRI图谱。San Diego：Academic Press）和基于表面的（货车埃森，D.C.（2002 a）人、猕猴和小鼠小脑皮质的基于表面的图谱。Ann.N. Y Acad.阿清978：468-479.）一个人的大脑图谱，“科林27”-大脑。(c)2006年爱思唯尔公司All rights reserved.
This article presents a new high-resolution atlas template of the human, cerebellum and brainstem, based on the anatomy of 20 young healthy individuals. The atlas is spatially unbiased, i.e., the location of each structure is equal to the expected location of that structure across individuals in MNI space, a result that is cross-validated with an independent sample of 16 individuals. At the same time, the new template preserves the anatomical detail of cerebellar structures through a nonlinear atlas generation algorithm. In comparison to current whole-brain templates, it allows for an improved voxel-by-voxel normalization for functional MRI and lesion analysis. Alignment to the template requires that the cerebellum and brainstem are isolated from the surrounding tissue, a process for which an automated algorithm has been developed. Compared to normalization to the MNI whole-brain template, the new method strongly improves the alignment of individual fissures, reducing their spatial spread by 60%, and improves the overlap of the deep cerebellar nuclei. Applied to functional MRI data, the new normalization technique leads to a 5-15% increase in peak t values and in the activated volume in the cerebellar cortex for movement vs. rest contrasts. This indicates that the new template significantly improves the overlap of functionally equivalent cerebellar regions across individuals. The template and software are freely available as an SPM-toolbox, which also allows users to relate the new template to the annotated volumetric (Schmahmann, J.D., Doyon, J., Toga, A., Petrides, M., Evans, A. (2000). MRI atlas of the human cerebellum. San Diego: Academic Press) and surface-based (Van Essen, D.C. (2002a) Surface-based atlases of cerebellar cortex in the human, macaque, and mouse. Ann. N. Y Acad. Sei. 978:468-479.) atlas of one individual, the "colin27"-brain. (c) 2006 Elsevier Inc. All rights reserved.