RNAsoft:: a suite of RNA secondary structure prediction and design software tools
RNAsoft:: a suite of RNA secondary structure prediction and design software tools
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DOI：
10.1093/nar/gkg612
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发表时间：
2003-07-01
影响因子：
14.9
通讯作者：
Hoos, HH
中科院分区：
文献类型：
--
作者：
Andronescu, M;Aguirre-Hernández, R;Hoos, HH
DNA和RNA链以新颖的方式用于构建纳米结构，作为聚合物文库中的分子标签和治疗方法。在这些应用中需要新的软件工具来预测和设计分子结构。RNAsoft程序套件提供了预测一对DNA或RNA分子的二级结构的工具，测试DNA和RNA分子的组合标签集没有不需要的二级结构，并设计RNA链折叠到给定的输入二级结构。这些工具是基于RNA二级结构形成的标准热力学模型。RNAsoft可以在http://www.RNAsoft.ca上找到。
DNA and RNA strands are employed in novel ways in the construction of nanostructures, as molecular tags in libraries of polymers and in therapeutics. New software tools for prediction and design of molecular structure will be needed in these applications. The RNAsoft suite of programs provides tools for predicting the secondary structure of a pair of DNA or RNA molecules, testing that combinatorial tag sets of DNA and RNA molecules have no unwanted secondary structure and designing RNA strands that fold to a given input secondary structure. The tools are based on standard thermodynamic models of RNA secondary structure formation. RNAsoft can be found online at http://www.RNAsoft.ca.