High resolution in vivo imaging of the lamina cribrosa.
High resolution in vivo imaging of the lamina cribrosa.
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DOI：
10.1016/j.sjopt.2011.07.007
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
S. C. Park;R. Ritch
中科院分区：
文献类型：
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作者：
S. C. Park;R. Ritch
筛板被认为是青光眼视网膜神经节细胞轴突损伤的主要部位。近年来，成像技术得到了稳步改进，使得层状结构的精细细节具有更高的分辨率。组织学研究已经阐明了LC结构的细节，无论是在正常的眼睛和青光眼的眼睛，但这样的研究是有限的样本量较小，进行前瞻性研究的难度更大，并在组织学处理过程中改变组织结构的可能性。我们回顾了文献描述的LC在灵长类动物和人类的眼睛使用在体成像设备，并提供了一个简要的解释成像技术和文章的主要结果。我们还讨论了每种成像方式的优点和局限性，包括视盘摄影，共焦扫描激光检眼镜（CSLO）和光学相干断层扫描（OCT）。这些模态提供了LC在体内的正面和/或横截面图像。增强型深度成像OCT最近在成像后段更深结构（包括LC）方面取得了重要进展。自适应光学已被采用在CSL 0和OCT成像中以校正眼像差，并且已经提高了LC图像的分辨率和对比度。后图像处理技术，以补偿光衰减和增强OCT图像的对比度，使更好地可视化的LC下的神经视网膜边缘，血管结构，和巩膜边缘。长波长探头OCT显示出良好的可视化LC与扫描源OCT结合时，提高了渗透性。造影剂增强可视化OCT中的选择性靶结构已经开发出来。所有这些技术都有很大的希望，改善在体内成像的LC和需要进一步的调查。
The lamina cribrosa (LC) is considered to be the principal site of retinal ganglion cell axon injury in glaucoma. Imaging technology has steadily improved in recent years, allowing greater resolution of fine details of laminar structure. Histological studies have elucidated the details of LC structure, both in normal and glaucomatous eyes, but such studies are limited by smaller sample size, greater difficulty of conducting prospective studies, and possibility of altered tissue architecture during histologic processing. We reviewed the literature describing the LC in primate and human eyes using in vivo imaging devices and provided a brief explanation of the imaging technology and main results of the articles. We also discuss the advantages and limitations of each imaging modality described, including optic disk photography, confocal scanning laser ophthalmoscopy (CSLO) and optical coherence tomography (OCT). These modalities provide en face and/or cross-sectional images of the LC in vivo. Enhanced depth imaging OCT has recently led to important advances in imaging deeper structures of the posterior segment, including the LC. Adaptive optics has been adopted in CSLO and OCT imaging to correct for ocular aberration and has improved resolution and contrast of the LC images. Post-image processing techniques to compensate for light attenuation and enhance contrast in OCT images enabled better visualization of the LC beneath the neuroretinal rim, vascular structures, and scleral rim. Long-wavelength probe OCT has shown good visualization of the LC with improved penetration when combined with swept-source OCT. Contrast agents for enhanced visualization of selective target structures in OCT have been developed. All these technologies hold great promise for improved in vivo imaging of the LC and require further investigation.