V1 surface size predicts GABA concentration in medial occipital cortex
V1 surface size predicts GABA concentration in medial occipital cortex
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DOI：
10.1016/j.neuroimage.2015.09.036
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发表时间：
2016-01-01
期刊：
影响因子：
5.7
通讯作者：
Pearson, Joel
中科院分区：
文献类型：
--
作者：
Bergmann, Johanna;Pilatus, Ulrich;Pearson, Joel
最近的许多研究已经建立了行为和初级视觉皮层（V1）的解剖结构之间的联系。然而，一项经常提出的批评是，这些研究对所观察到的关系的机制几乎没有提供深入的了解。由于抑制性神经相互作用被认为是与 V1 解剖相关的行为的重要机制，因此我们使用磁共振波谱 (MRS) 测量了 V1 所在的内侧枕叶皮层中抑制性γ氨基丁酸 (GABA) 的浓度，并使用功能磁共振成像视网膜专题图估计了 V1 的表面积。我们发现 GABA 浓度和 V1 表面积之间存在显着的正相关关系。无论 MRS 体素在参与者中是否具有固定大小，还是与每个个体的 V1 表面积成比例，都存在这种关系。因此，V1 较大的个体内侧枕叶皮质中的 GABA 浓度较高。通过将 V1 大小和 GABA 浓度联系在一起，我们的研究结果指出了神经抑制水平的个体差异，这可能部分介导了行为和 V1 神经解剖学之间的关系。此外，它们还说明了神经活动和功能的稳定微观特性如何反映在 V1 结构的宏观测量中。 (C) 2015 Elsevier Inc. 保留所有权利。
A number of recent studies have established a link between behavior and the anatomy of the primary visual cortex (V1). However, one often-raised criticism has been that these studies provide little insight into the mechanisms of the observed relationships. As inhibitory neural interactions have been postulated as an important mechanism for those behaviors related to V1 anatomy, we measured the concentration of inhibitory gammaamino butyric acid (GABA) in the medial occipital cortex where V1 is located using magnetic resonance spectroscopy (MRS) and estimated the surface area of V1 using fMRI retinotopic mapping. We found a significant positive relationship between GABA concentration and V1 surface area. This relationship was present irrespective of whether the MRS voxel had a fixed size across participants or was proportionally sized to each individual's V1 surface area. Hence, individuals with a larger V1 had a higher GABA concentration in the medial occipital cortex. By tying together V1 size and GABA concentration, our findings point towards individual differences in the level of neural inhibition that might partially mediate the relationships between behavior and V1 neuroanatomy. In addition, they illustrate how stable microscopic properties of neural activity and function are reflected in macro-measures of V1 structure. (C) 2015 Elsevier Inc. All rights reserved.