Caucasian genes in American blacks: new data.
Caucasian genes in American blacks: new data.
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发表时间：
1992
影响因子：
9.8
通讯作者：
Ranajit Chakraborty;M. Kamboh;M. Nwankwo;R. Ferrell
中科院分区：
文献类型：
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作者：
Ranajit Chakraborty;M. Kamboh;M. Nwankwo;R. Ferrell
15个多态蛋白质编码基因座的数据被用来估计来自匹兹堡大都市地区的美国黑人中高加索基因的比例。来自同一地区的美国白人和尼日利亚样本的等位基因频率被用来代表发生了混合的源群体的遗传贡献。这些材料提供了18个仅在黑人中出现的独特变体和5个仅限于高加索人的变体。因此，当考虑到这15个基因座上的所有分离等位基因(52个)时，估计美国黑人高加索基因的比例(平均值+/-SE)(25.2%+/-2.7%)的精度远远好于所有其他先前的估计。根据这18个非洲起源的独特变异的频率(24.8%+/-6.2%)进行的估计也与用加权最小二乘法从15个基因座得到的综合估计值一致。混合基因位点特异性估计的同质性表明，这些基因座适合于研究任何涉及非洲混合基因的混合种群中黑人基因的比例。在美国黑人中使用这些基因座进行遗传流行病学研究的优势是在这些蛋白基因座上存在大量独特的非洲变异的背景下讨论的。
Data on 15 polymorphic protein-coding loci are used to estimate the proportion of Caucasian genes in U.S. blacks from the greater-metropolitan area of Pittsburgh. Allele frequencies from U.S. whites of the same region and from a sample of Nigerians are used as representatives of the genetic contributions of the source populations between which admixture has occurred. These materials provide 18 unique variants that occur exclusively in the blacks and 5 variants that are restricted to the Caucasians only. As a result, when all segregating alleles (52) at these 15 loci are considered, the proportion (mean +/- SE) of Caucasian genes in U.S. blacks (25.2% +/- 2.7%) is estimated with a precision much better than that of all other previous estimates. The estimate based on the frequencies of these 18 unique variants of African origin (24.8% +/- 6.2%) is also consistent with the pooled estimate obtained from the 15 loci by the weighted least-square method. The homogeneity of locus-specific estimates of admixture indicates that these loci are appropriate for studying the proportion of black genes in any admixed population involving African admixture. The advantages of employing such loci for genetic-epidemiologic studies in U.S. blacks is discussed in the context of the availability of these large number of unique African variants at these protein loci.