Antimullerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause
Antimullerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause
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DOI：
10.1016/j.fertnstert.2015.10.017
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发表时间：
2016-02-01
影响因子：
6.7
通讯作者：
Chen, Zi-Jiang
中科院分区：
文献类型：
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作者：
Cui, Linlin;Qin, Yingying;Chen, Zi-Jiang
设计：横断面研究。地点：大学医院。患者(S)：共6,763名中国妇女从出生到绝经。干预(S)：无。主要观察指标(S)：人体测量参数(身高、体重、血压)，以及男性激素和睾酮水平、糖代谢和血脂水平。结果(S)：根据AMH水平划分为四个年龄阶段：儿童期(0-10岁)，青春期(11-18岁)，生育年龄(19-50岁)和高龄(>；=51岁)。在儿童期和青春期，AMH水平升高，在18岁时达到峰值。此后，在生育期至50岁期间出现下降，并保持在0以上的较低水平。结果发现，儿童AMH与睾酮呈负相关(r=-0.25)，青春期(r=0.30；r=0.26)和生殖期(r=0.28；r=0.31)与睾酮和游离雄激素指数呈正相关(r=0.30；r=0.26)。各时相体质量指数、空腹血糖、空腹胰岛素、稳态模型评分、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白与黄体质量指数、空腹血糖、空腹胰岛素均无相关性。结论：S出生至18岁，黄体生成素水平先升高后下降，提示卵巢维持功能的改变。在青春期和生殖年间，雄激素谱与AMH呈正相关，暗示雄激素与卵巢储备之间存在同步性。(C)2016年由美国生殖医学会评选。
Objective: To study the age-specific distribution of antimullerian hormone (AMH) and describe the association of AMH with androgenic and metabolic profiles at different ages.Design: Cross-sectional study.Setting: University hospital.Patient(s): A total of 6,763 Chinese women from birth to menopause.Intervention(s): None.Main Outcome Measure(s): Anthropometric parameters (height, weight, and blood pressure), and levels of AMH and testosterone, glucose metabolism, and lipid profiles.Result(s): According to the level of AMH, four age phases were established: childhood (0-10 years), adolescence (11-18 years), reproductive age (19-50 years), and advanced age (>= 51 years). During childhood and adolescence, AMH levels increased, reaching a peak at 18 years. A decline occurred thereafter during the reproductive-age period until the age of 50 years, and it remained at a low level above 0 onward. We found that AMH was negatively correlated with testosterone in childhood (r = -0.25), but was positively correlated with testosterone and the free androgen index in adolescence (r = 0.30; r = 0.26, respectively) as well as during the reproductive phases (r = 0.28; r = 0.31, respectively). No correlation was observed between AMH and body mass index, fasting blood glucose, fasting insulin, the homeostasis model assessment, total cholesterol, triglycerides, low-density lipoprotein, or high-density lipoprotein at any phase.Conclusion(s): From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve. (C) 2016 by American Society for Reproductive Medicine.