Homocysteine level in patients with obstructive sleep apnea/hypopnea syndrome and the impact of continuous positive airway pressure treatment
Homocysteine level in patients with obstructive sleep apnea/hypopnea syndrome and the impact of continuous positive airway pressure treatment
复制标题
阻塞性睡眠呼吸暂停/低通气综合征患者同型半胱氨酸水平及持续气道正压通气治疗的影响
DOI：
10.17219/acem/74178
复制
发表时间：
2018-11-01
影响因子：
2.1
通讯作者：
Fang, Qi
中科院分区：
文献类型：
--
作者：
Li, Jie;Yu, Li-Qiang;Fang, Qi
背景阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是普通人群中常见的疾病。本研究旨在探讨不同程度OSAHS患者血浆同型半胱氨酸（Hcy）水平及持续气道正压通气（CPAP）治疗对OSAHS患者的影响。将117例OSAHS患者分为轻度OSAHS组、中度OSAHS组和重度OSAHS组，并选择33例非OSAHS患者作为对照组。记录多导睡眠图（PSG）参数及Hcy、丙二醛（MDA）和谷胱甘肽（GSH）浓度。采用环磷酸酶法测定血清Hcy水平。用分光光度计测定MDA和GSH的含量。重度OSAHS组30例，每晚CPAP治疗4 h以上，6个月后复查。OSAHS组与对照组血清Hcy、MDA、GSH水平差异有统计学意义。CPAP治疗后OSAHS患者Hcy、GSH水平与治疗前相比无明显变化，MDA水平明显降低。多元线性回归分析结果显示，在对照组和轻中度OSAHS组中，Hcy浓度与各自变量（年龄、MDA、GSH和呼吸暂停低通气指数AHI）之间存在统计学意义。不同OSAHS组Hcy水平的变化与病情严重程度不成正比，CPAP治疗对Hcy水平无明显影响。
Background. Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a common disorder in the general population.Objectives. The aim of this study wasto investigate the homocysteine (Hcy) level in the patients with OSAHS of varying degrees and the effect of continuous positive airway pressure (CPAP) treatment on OSAHS patients.Material and methods. A total of 117 OSAHS patients were recruited and divided into 3 groups (mild OSAHS, moderate OSAHS and severe OSAHS), while 33 non-OSAHS people were selected as control group. For all cases, polysomnography (PSG) variables and the concentrations of Hcy, methane dicarboxylicaldehyde (MDA) and glutathione (GSH) were recorded. Serum Hcy was measured by cyclophorase. The values of MDA and GSH were measured by a spectrophotometer. In the severe OSAHS group, a total of 30 patients received CPAP for more than 4 h every night and were re-examined 6 months later.Results. The serum levels of Hcy, MDA and GSH showed a significant difference in OSAHS patients and controls. The Hcy and GSH concentrations of OSAHS patients with CPAP treatment showed no apparent change compared with the prior treatment, but the MDA level was obviously lower after CPAP treatment. In controls and the mild/moderate OSAHS groups, multi-element linear regression analysis results indicated that there was a statistically significant relationship between the Hcy concentration and various independent variables (age, MDA, GSH, and the apnea-hypopnea index - AHI).Conclusions. The change of the Hcy level was not proportional to the severity of the disease in different groups of OSAHS patients, and CPAP did not affect the Hcy levels.