Oestrogen receptors in breast tumours: associations with age, menopausal status and epidemiological and clinical features in 735 patients.
Oestrogen receptors in breast tumours: associations with age, menopausal status and epidemiological and clinical features in 735 patients.
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DOI：
10.1038/bjc.1980.296
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发表时间：
1980-11
影响因子：
8.8
通讯作者：
Godolphin, W
中科院分区：
文献类型：
--
作者：
Elwood, J M;Godolphin, W
对1975年至1978年在不列颠哥伦比亚省主要治疗中心就诊的735例原发性乳腺肿瘤患者进行雌激素受体（RE）阳性或阴性患者的比较。RE阳性在老年患者中更常见，并且与年龄无关的绝经状态无关。受体蛋白的浓度也随着年龄的增加而增加，但不受绝经状态的影响。RE的状态和数量与研究的任何流行病学风险因素均不相关，这些因素包括产次、首次生育年龄、体重、家族史以及暴露于雌激素药物和口服避孕药。RE-肿瘤患者更有可能出现乳房肿块、疼痛或乳头内陷以外的症状，并且肿瘤分化程度较低;他们与RE+患者在分期、肿瘤大小或首次症状间隔方面没有差异。这些研究结果进行了讨论的生物起源和雌激素受体的决定因素。
Comparisons between oestrogen-receptor (RE)-positive or negative patients were made on a continuous series of 735 patients with primary breast tumours seen at the major treatment centre in British Columbia between 1975 and 1978. RE positivity was commoner in older patients, and was not associated with menopausal status independently of age. The concentration of receptor protein also increased with increasing age, but was not affected by menopausal status. Neither RE status nor quantity was associated with any of the epidemiological risk factors studied, which included parity, age at first birth, weight, family history and exposure to oestrogenic drugs and oral contraceptives. Patients with RE- tumours were more likely to present with symptoms other than a breast lump, pain or nipple inversion, and had less-differentiated tumours; they did not differ from RE+ patients in terms of stage, size of tumour, or interval from first symptom. These findings are discussed in terms of the biological origin and determinants of oestrogen receptors.