Loss of intercellular bridges in the depth of invasion measurement area is a novel negative prognostic factor for oral squamous cell carcinoma: A retrospective study
Loss of intercellular bridges in the depth of invasion measurement area is a novel negative prognostic factor for oral squamous cell carcinoma: A retrospective study
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DOI：
10.1016/j.oooo.2022.02.017
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发表时间：
2022-07-01
影响因子：
2.9
通讯作者：
Ueki, Koichiro
中科院分区：
文献类型：
--
作者：
Yoshizawa, Kunio;Kimura, Yujiro;Ueki, Koichiro
目标。本研究旨在评估口腔鳞状细胞癌(OSCC)侵袭深度(DOI)测量区域的细胞间桥作为预后因素。研究设计。根据Yamamoto-Kohama分类系统，观察78例口腔鳞癌标本苏木精-伊红染色的全片图像，确定口腔鳞癌的侵袭方式，并对其临床病理特征进行分析。本文分析了46例Yamamoto-Kohama分级为GT；3级的患者的肿瘤细胞间桥的存在，通过将测量区域分为肿瘤表面、肿瘤中心和肿瘤前部来测量其DOI。结果。单变量分析发现，淋巴结转移、DOI测量区细胞间桥丢失、DOI为4500 mm、侵袭方式为4C-4D为阴性预后因素。多因素分析显示，全区淋巴结转移和细胞间桥丢失是独立的危险因素，其危险性比分别为9.34(95%可信区间，2.09~42.03；P=0.003)和3.64(95%可信区间，1.10~11.99；P=0.045)。结论。口腔鳞状细胞癌DOI测量区细胞间桥的丢失是口腔鳞癌的一个负面预后因素，可能有助于选择治疗方法。
Objective. This study aimed to evaluate intercellular bridges in the depth of invasion (DOI) measurement area as prognostic factors in oral squamous cell carcinoma (OSCC). Study Design. The mode of invasion was determined based on the Yamamoto-Kohama classification system by observing the hematoxylin-eosin-stained whole-slide images of specimens obtained from 78 patients with OSCC, and the clinicopathologic features were characterized. The presence of intercellular bridges was analyzed in 46 patients with Yamamoto-Kohama classification grade > 3 whose DOI was measured by dividing the measurement area into 3 parts: the surface, center, and front of the tumor. Results. Univariate analyses identified lymph node metastasis, loss of intercellular bridges in the DOI measurement area, DOI of > 4500 mm, and pattern of invasion 4C-4D as negative prognostic factors. Multivariate analyses revealed that lymph node metastasis and the loss of intercellular bridges in the entire area were independent factors, with hazard ratios of 9.34 (95% confidence interval, 2.09-42.03; P = .003) and 3.64 (95% confidence interval, 1.10-11.99; P = .045), respectively. Conclusions. Loss of intercellular bridges in the DOI measurement area is a negative prognostic factor for OSCC and may be useful in selecting treatment.