Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002
Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002
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DOI：
10.1007/s00125-007-0755-4
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发表时间：
2007-09-01
期刊：
影响因子：
8.2
通讯作者：
Jacobs, D. R., Jr.
中科院分区：
文献类型：
--
作者：
Lee, D.-H.;Lee, I.-K.;Jacobs, D. R., Jr.
目的/假设我们最近报道了一些持久性有机污染物（POP）与2型糖尿病和胰岛素抵抗的患病率在美国人口背景暴露于POPs的协会。仅限于非糖尿病参与者，我们现在调查之间的关系持久性有机污染物和代谢综合征，prediabetic state.Materials和方法横断面协会进行了调查，在721名非糖尿病参与者年龄>= 20岁。在五个亚类的19个持久性有机污染物被选中，因为他们是在>= 60%的participators.Results检测五个持久性有机污染物亚类，有机氯（OC）农药是最强烈的，始终与代谢综合征：调整后的优势比（OR）的1.0，1.5，2.3和5.3 OC农药四分位数（P趋势< 0.01）。二恶英类多氯联苯（PCB）也与调整后的OR值1.0、1.1、2.2和2.1呈正相关（趋势p =0.01）。然而，非二恶英类多氯联苯显示出倒U形关联，调整后的OR为1.0、1.3、1.8和1.0（二次项p < 0.01）。特定持久性有机污染物的关联在代谢综合征的五个组成部分中各不相同。OC农药与五种成分中的四种呈显著正相关，尤其是三酰甘油升高和空腹血糖升高，但与高血压无关。多氯联苯与腰围、三酰甘油和空腹血糖受损显著相关。多氯二苯并对二恶英和多氯二苯并呋喃表现出小，但显着的协会只有高血压。结论/解释-这项研究表明，一组心血管危险因素的患病率与背景暴露的混合物的持久性有机污染物，其中几个也与糖尿病的患病率。持久性有机污染物与代谢综合征的不同组成部分差异相关。
Aims/hypothesis We recently reported associations of some persistent organic pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance in a US population with background exposure to POPs. Restricted to non-diabetic participants, we now investigate the relationship between POPs and the metabolic syndrome, a prediabetic state.Materials and methods Cross-sectional associations were investigated in 721 non-diabetic participants aged >= 20 years. Nineteen POPs in five subclasses were selected because they were detectable in >= 60% of participants.Results Among five POPs subclasses, organochlorine (OC) pesticides were most strongly and consistently associated with metabolic syndrome: adjusted odds ratios (ORs) of 1.0, 1.5, 2.3 and 5.3 across OC pesticide quartiles (p for trend < 0.01). Dioxin-like polychlorinated biphenyls (PCBs) were also positively associated with adjusted ORs of 1.0, 1.1, 2.2 and 2.1 (p for trend=0.01). However, non-dioxin-like PCBs showed an inverted U-shaped association with adjusted ORs of 1.0, 1.3, 1.8 and 1.0 (p for quadratic term < 0.01). Associations of specific POPs varied across five components of the metabolic syndrome. OC pesticides were positively and significantly associated with four of the five components, especially elevated triacylglycerol and high fasting glucose, but not high blood pressure. PCBs were significantly associated with waist circumference, triacylglycerol and impaired fasting glucose. Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans showed small but significant associations only with high blood pressure.Conclusions/interpretation This study suggests that the prevalence of a cluster of cardiovascular risk factors relates to background exposure to a mixture of POPs, several of which are also related to the prevalence of diabetes. POPs associated differentially with different components of the metabolic syndrome.