Prenatal stress and adult drug-seeking behavior: interactions with genes and relation to nondrug-related behavior.
Prenatal stress and adult drug-seeking behavior: interactions with genes and relation to nondrug-related behavior.
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DOI：
10.1007/978-1-4939-1372-5_5
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发表时间：
2015-01-01
影响因子：
--
通讯作者：
Bagley, Jared
中科院分区：
文献类型：
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作者：
Kippin, Tod E;Campbell, Jaonnalee C;Bagley, Jared
成瘾造成巨大的个人，社会和经济负担，但其病因定义不清，缺乏有效的治疗方法。与其他神经精神疾病一样，成瘾的特征是一组核心症状和行为，这些症状和行为被认为受到复杂的基因-环境相互作用的影响。我们的小组专注于早期压力和遗传背景在确定成瘾脆弱性方面的相互作用。我们小组和其他人先前的工作表明，啮齿动物的产前应激史（PNS）在许多行为范式中提高了成年人的药物寻求。本章的重点是总结在该地区的PNS和成瘾模型，以及我们最近的研究PNS药物寻求不同品系的小鼠作为一种策略，解剖基因-环境相互作用的可卡因成瘾的脆弱性。这些研究表明，PNS提高成人可卡因寻求的能力是依赖于应变的。此外，PNS还改变了其他非药物行为的方式，这是依赖于不同的应变和独立的应变依赖性药物寻求。因此，看来PNS改变与不同精神状况相关的行为的能力是正交的，在遗传背景中对产前应激具有相似的非特异性易感性，但遗传背景决定了PNS效应的特定性质。最后，重组近交系小鼠品系的出现使我们能够确定这些基因-环境相互作用的遗传基础。了解这些影响将对确定成瘾和其他疾病的脆弱性具有广泛的意义。
Addiction inflicts large personal, social, and economic burdens, yet its etiology is poorly defined and effective treatments are lacking. As with other neuropsychiatric disorders, addiction is characterized by a core set of symptoms and behaviors that are believed to be influenced by complex gene-environment interactions. Our group focuses on the interaction between early stress and genetic background in determining addiction vulnerability. Prior work by our group and others has indicated that a history of prenatal stress (PNS) in rodents elevates adult drug seeking in a number of behavioral paradigms. The focus of the present chapter is to summarize work in the area of PNS and addiction models as well as our recent studies of PNS on drug seeking in different strains of mice as a strategy to dissect gene-environment interactions underlying cocaine addiction vulnerability. These studies indicate that ability of PNS to elevate adult cocaine seeking is strain dependent. Further, PNS also alters other nondrug behaviors in a fashion that is dependent on different strains and independent from the strain dependence of drug seeking. Thus, it appears that the ability of PNS to alter behavior related to different psychiatric conditions is orthogonal, with similar nonspecific susceptibility to prenatal stress across genetic backgrounds but with the genetic background determining the specific nature of the PNS effects. Finally, the advent of recombinant inbred mouse strains is allowing us to determine the genetic bases of these gene-environment interactions. Understanding these effects will have broad implications to determining the nature of vulnerability to addiction and perhaps other disorders.