Calbindin-D in peripheral nerve cells is vitamin D and calcium dependent.
Calbindin-D in peripheral nerve cells is vitamin D and calcium dependent.
复制标题
周围神经细胞中的钙结合蛋白-D 依赖于维生素 D 和钙。
DOI：
10.1073/pnas.84.20.7344
复制
发表时间：
1987
影响因子：
11.1
通讯作者：
Wasserman,RH
中科院分区：
文献类型：
--
作者：
Lee,YS;Taylor,AN;Reimers,TJ;Edelstein,S;Fullmer,CS;Wasserman,RH
维生素D诱导的钙结合蛋白钙结合蛋白D（CaBP）定位在一些，但不是所有的细胞体和轴突内的神经节的鸡。与其他神经组织，到目前为止检查，钙BP含量的延髓神经减少维生素D缺乏和增加鸡适应钙缺乏的饮食。这些变化在性质上类似于肠细胞的反应模式。在十二指肠腔内包含含钙溶液直接或间接导致该神经中CaBP的量以剂量依赖性方式减少。CaBP在神经元细胞中的确切作用尚不清楚，但可能是在兴奋期间调节细胞内离子Ca2+浓度，尽管不能排除CaBP的其他功能。
The vitamin D-induced calcium-binding protein calbindin-D (CaBP) was localized immunohistochemically in some but not all of the cell bodies and axons within the intestinalis nerve of the chicken. Unlike other nerve tissue thus far examined, the CaBP content of the intestinalis nerve was decreased in vitamin D deficiency and increased in chicken adapted to a calcium-deficient diet. These changes are qualitatively similar to the pattern of response of enterocytes. The inclusion of calcium-containing solutions within the duodenal lumen caused, directly or indirectly, a decrease in the amount of CaBP in this nerve in a dose-dependent manner. The exact role of CaBP in intestinalis nerve cells is unknown but may be in the regulation of intracellular ionic Ca2+ concentrations during excitation, although other functions of CaBP cannot be excluded.