Impact of previous, simultaneous or intravesical recurrence bladder cancer on prognosis of upper tract urothelial carcinoma after nephroureterectomy: a large population-based study.
Impact of previous, simultaneous or intravesical recurrence bladder cancer on prognosis of upper tract urothelial carcinoma after nephroureterectomy: a large population-based study.
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既往、同时或膀胱内复发膀胱癌对肾输尿管切除术后上尿路尿路上皮癌预后的影响：一项基于大规模人群的研究
DOI：
10.21037/tau-21-758
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发表时间：
2021-12
影响因子：
2
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Zeng S;Ying Y;Yu X;Wang L;Zhang Z;Xu C
目前，既往膀胱癌、同时膀胱癌或继发膀胱癌对上尿路尿路上皮癌（UTUC）预后的影响存在争议。我们的目的是基于来自监测、流行病学和最终结果（SEER）数据库的大型人群队列，研究既往、同时或膀胱内复发（IVR）膀胱癌对UTUC预后的影响。方法基于SEER数据库，对2004 - 2018年诊断为UTUC的8431例符合纳入标准的患者进行筛选。我们采用Kaplan-Meier法和倾向评分匹配（PSM）评估膀胱癌对UTUC预后的影响。结果共6831例患者仅存在UTUC (UTUC-only)， 880例患者同时存在膀胱癌（UTUC- bca）， 720例患者存在IVR （UTUC-IVR）。在调整各组间差异显著的基线协变量后，我们发现无论肿瘤分级和分期如何，UTUC-Bca队列的预后都比仅UTUC-Bca队列差。总的来说，我们证明与无IVR的PSM匹配患者相比，IVR对UTUC的预后没有显著影响。然而，亚组分析显示，与仅UTUC的队列相比，随后发生MIBC复发或UTUC与IVR之间间隔时间较短（<20个月）的UTUC患者预后更差。结论UTUC合并膀胱癌或同时膀胱癌患者、IVR合并MIBC、UTUC与IVR间隔较短是预后较差的重要预测因素。因此，对于存在这些危险因素的UTUC患者，应考虑更严格的术后监测和积极的治疗策略。
Background Currently, the impact of previous, simultaneous, or subsequent bladder cancer on the prognosis of upper urinary tract urothelial carcinoma (UTUC) is controversial. We aimed to investigate the impact of previous, simultaneous or intravesical recurrence (IVR) bladder cancer on the prognosis of UTUC based on a large population-based cohort from the Surveillance, Epidemiology, and End Results (SEER) database. Methods A total of 8,431 UTUC patients diagnosed from 2004 to 2018 met the inclusion criteria were identified based on the SEER database. We evaluated the impact of bladder cancer on the prognosis of UTUC by Kaplan-Meier method and propensity score matching (PSM). Results In all, 6,831 patients only had UTUC (UTUC-only), 880 patients with previous or simultaneous bladder cancer (UTUC-Bca), 720 patients with IVR (UTUC-IVR). After adjusting baseline covariates that varied significantly among groups, we found UTUC-Bca cohort, regardless of tumor grade and stage, had poorer prognosis than UTUC-only cohort. In general, we demonstrated IVR had no significant impact on the prognosis of UTUC compared to PSM matched patients without IVR. However, subgroup analysis revealed that UTUC patients with subsequent MIBC recurrence or shorter interval (<20 months) between UTUC and IVR had worse prognosis compared with UTUC-only cohort. Conclusions UTUC patients with previous or simultaneous bladder cancer, IVR with MIBC, and shorter interval between UTUC and IVR were significant predictor for worse prognosis. Thus, more stringent postoperative surveillance and active treatment strategies should be considered for UTUC patients with those risk factors.
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影响因子：
2.7
作者：
Yoo, Sangjun;You, Dalsan;Jeong, In Gab
通讯作者：
Jeong, In Gab
影响因子：
2.6
作者：
Yamashita, Shinichi;Ito, Akihiro;Arai, Yoichi
通讯作者：
Arai, Yoichi
DOI：
10.1016/j.urolonc.2012.08.010
发表时间：
2014-01-01
影响因子：
2.7
作者：
Pignot, Geraldine;Colin, Pierre;Roupret, Morgan
通讯作者：
Roupret, Morgan
影响因子：
3.9
作者：
Yu LC;Chang CH;Huang CP;Huang CY;Hong JH;Tai TY;Weng HY;Lo CW;Tsai CY;Lee YK;Tsai YC;Hsueh TY;Chen YT;Chen IH;Chiang BJ;Tseng JS;Wu CC;Lin WY;Chien TM;Sheu ZL;Li CC;Ke HL;Li WM;Lee HY;Wu WJ;Yeh HC
通讯作者：
Yeh HC
影响因子：
1.6
作者：
Hirano, Daisaku;Okada, Yasuhiro;Henmi, Akihiro
通讯作者：
Henmi, Akihiro