Transport of LRF from CSF to hypophysial portal and systemic blood and the release of LH.
Transport of LRF from CSF to hypophysial portal and systemic blood and the release of LH.
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LRF 从 CSF 转运至垂体门静脉和全身血液并释放 LH。
DOI：
10.1210/endo-95-1-18
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发表时间：
1974
期刊：
影响因子：
4.8
通讯作者：
John C. Porter
中科院分区：
文献类型：
--
作者：
Nira Ben;R. S. Mical;John C. Porter
研究了正中隆起将 LRF 从 CSF 转运至垂体门静脉血的能力以及心室内和静脉注射 LRF 释放 LH 的功效。脑室内注射 125 ng LRF 10 至 15 分钟后，在门静脉血中检测到 LRF。最大传输速率范围为 35 至 200 pg'min 以上。施用 25 或 5 ng LRF 后，转运率要低得多。当这些相同量的 LRF 被注射到具有完整垂体的大鼠脑室内时，血浆 LH 水平与 LRF 剂量成比例增加。 LRF的释放作用较长，给予125ng LRF后120分钟，血浆LH浓度比对照水平高40至50倍。静脉注射 5、25 或 125 ng LRF 会导致 LH 释放相应增加。静脉注射 LRF 刺激 LH 释放的速度略快于心室内注射 LRF，但心室内注射的效果...
The capacity of the median eminence to transport LRF from CSF to hypophysial portal blood and the efficacy of intraventricularly and intravenously administered LRF in releasing LH were studied. Ten to 15 min after 125 ng LRF was injected intraventricularly, LRF was detected in portal blood. The maximal rate of transport ranged from 35 to more than 200 pg'min. The rates of transport were much less following the administration of 25 or 5 ng LRF. When these same quantities of LRF were injected intraventricularly into rats with intact pituitary glands, plasma LH levels increased in proportion to the dose of LRF. The releasing action of LRF was long, and 120 min after the administration of 125 ng LRF, the concentration of plasma LH was 40- to 50-fold greater than the control level. Intravenous injection of 5, 25, or 125 ng LRF caused corresponding increases in LH release. Intravenously administered LRF stimulated LH release slightly faster than did LRF given intraventricularly, but the effect of intraventricul...