Large cell sarcomas of tendon sheath. Malignant giant cell tumors of tendon sheath.
Large cell sarcomas of tendon sheath. Malignant giant cell tumors of tendon sheath.
复制标题
腱鞘大细胞肉瘤。
DOI：
10.1093/ajcp/49.6.776
复制
发表时间：
1968
影响因子：
3.5
通讯作者：
R. Reed
中科院分区：
文献类型：
--
作者：
Bryce O. Bliss;R. Reed
多种肿瘤可能与关节滑膜和肌腱鞘有关。良性骨巨细胞瘤是最常见的起源于滑膜的肿瘤，但通常不被认为是真正的肿瘤。滑膜肉瘤表现为滑膜样分化，但矛盾的是，它们很少与关节或腱鞘的滑膜直接连续生长。粘液肉瘤和软骨肉瘤偶尔发生于腱鞘，但不是这些结构所特有的。肌腱鞘起源的恶性骨巨细胞瘤已有报道，8但大多数报道的病例尚未转移。6报告手腕腱鞘恶性肿瘤4例。在临床和组织学上，这些肿瘤与良性腱鞘巨细胞瘤有着惊人的相似之处。它们似乎是特定的肌腱鞘恶性肿瘤，但在组织学上并不像常见的滑膜肉瘤。肿瘤广泛渗入淋巴管，临床表现为皮肤淋巴扩散和淋巴水肿。在尸检中，血源性转移是显著的。
A variety of tumors may be associated with the synovia of joints and tendon sheaths. Benign giant cell tumors are the most common tumefactions originating from the synovia, but they are not generally accepted as true neoplasms. 7 Synovial sarcomas show evidence of synovial-like differentiation but, paradoxically, they seldom grow in direct continuity with the synovial membrane of a joint or tendon sheath. 7 Myxosarcomas and chondrosarcomas occasionally arise from tendon sheaths but are not specific for these structures. Malignant giant cell tumors of tendon sheath origin have been reported, 8 but most of the reported examples have not metastasized. 6 Four examples of malignant tumors arising from the tendon sheaths of the hand and wrist are reported. Clinically and histologically these tumors show a remarkable resemblance to benign giant cell tumors of tendon sheath. They appear to be specific malignant neoplasms of tendon sheath but histologically do not resemble the usual synovial sarcoma. The tumors show extensive permeation into lymphatic vessels and produce a clinical picture of cutaneous lymphatic spread and lymphedema. Hematogenous metastases are prominent at autopsy.