Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding.
Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding.
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DOI：
10.1038/s41467-021-25497-4
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发表时间：
2021-09-02
影响因子：
16.6
通讯作者：
von Messling V
中科院分区：
文献类型：
--
作者：
Wittwer K;Anderson DE;Pfeffermann K;Cox RM;Wolf JD;Santibanez S;Mankertz A;Plesker R;Sticher ZM;Kolkykhalov AA;Natchus MG;Pfaller CK;Plemper RK;von Messling V
麻疹病毒（MeV）是一种传染性极强的病原体，通过呼吸道途径进入人体宿主。除了发热、咳嗽以及特征性麻疹皮疹等急性病症外，淋巴细胞感染会导致严重的免疫抑制，进而可能使其他病原体感染的后果恶化。尽管已有有效的疫苗预防措施，但麻疹疫情仍在全球范围内不断发生。我们证明，使用一种口服生物可利用的小分子聚合酶抑制剂ERDRP - 0519进行预防性和暴露后治疗，可预防松鼠猴（松鼠猴属）患上麻疹。在临床症状出现时开始治疗，可减少病毒传播，这可能有助于疫情控制。研究结果表明，这种临床候选药物有潜力缓解麻疹临床症状并助力根除麻疹病毒。
麻疹病毒传染性极强，全球范围内时有疫情发生。本文作者表明，口服生物可利用的小分子聚合酶抑制剂ERDRP - 0519可预防松鼠猴患上麻疹，并减少病毒传播。
Measles virus (MeV) is a highly contagious pathogen that enters the human host via the respiratory route. Besides acute pathologies including fever, cough and the characteristic measles rash, the infection of lymphocytes leads to substantial immunosuppression that can exacerbate the outcome of infections with additional pathogens. Despite the availability of effective vaccine prophylaxis, measles outbreaks continue to occur worldwide. We demonstrate that prophylactic and post-exposure therapeutic treatment with an orally bioavailable small-molecule polymerase inhibitor, ERDRP-0519, prevents measles disease in squirrel monkeys (Saimiri sciureus). Treatment initiation at the onset of clinical signs reduced virus shedding, which may support outbreak control. Results show that this clinical candidate has the potential to alleviate clinical measles and augment measles virus eradication. Measles virus is highly contagious and outbreaks occur worldwide. Here the authors show that the orally bioavailable small-molecule polymerase inhibitor ERDRP-0519 prevents measles disease in squirrel monkeys and reduces virus shedding.
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