Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men
Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men
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DOI：
10.1038/sj.jhh.1002242
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发表时间：
2007-12-01
影响因子：
2.7
通讯作者：
Yamada, Y.
中科院分区：
文献类型：
--
作者：
Noborisaka, Y.;Honda, R.;Yamada, Y.
在对2133名中年健康男性的横断面观察中，随着饮酒和吸烟的增加，血清肌酐降低，Cockcroft和Gault公式计算的肌酐清除率（Ccr）增加。虽然在没有吸烟习惯的饮酒者中没有观察到Ccr与血压（BP）的相关性，但在吸烟者中，无论饮酒与否，BP均随Ccr的增加而增加。需要进一步研究，因为Ccr和BP的联合升高可能与高血压吸烟者肾功能的进行性恶化有关。
In a cross-sectional observation on 2133 middle-aged healthy men, serum creatinine was decreased and creatinine clearance (Ccr) calculated by Cockcroft and Gault formula was increased with increases in alcohol and cigarette consumption. Although no association of Ccr with blood pressure (BP) was observed in drinkers without smoking habit, BP was increased with increases in Ccr in smokers irrespective of alcohol consumption. Further studies are required because the combined elevations of Ccr and BP may relate to the progressive deterioration of renal function in hypertensive smokers.