Validation of a new strength measurement device for amyotrophic lateral sclerosis clinical trials
Validation of a new strength measurement device for amyotrophic lateral sclerosis clinical trials
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DOI：
10.1002/mus.22253
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发表时间：
2012-01-01
期刊：
影响因子：
3.4
通讯作者：
Cudkowicz, Merit E.
中科院分区：
文献类型：
--
作者：
Andres, Patricia L.;Skerry, Linda M.;Cudkowicz, Merit E.
简介：具有减少变异性和更高灵敏度的力量测量可以提高肌萎缩侧索硬化症 (ALS) 临床试验的效率。肢体等长力量精确测试 (ATLIS) 旨在精确、方便地测量 12 个肌肉群的力量。在本研究中，我们评估 ATLIS 测试协议的可靠性和有效性。方法：20 名健康成人和 10 名 ALS 患者由相同或不同的评估者进行两次测试，以确定重测和评估者间的可靠性。使用 ATLIS 和经过充分验证的力量测试方案 (TQNE) 对 20 名健康成年人进行了检查，以评估基于标准的有效性。结果：测试之间的平均绝对变异为 8.6%，每个肌肉群的组内相关系数很高（范围 0.82-0.99）。平均 ATLIS 和 TQNE 评分的 Pearson 相关系数为 0.90。一项主题调查表明，用户对 ATLIS 的接受度很高。结论：ATLIS 对于患者和评估人员来说很方便，可以产生精确的力量测量，并且可以在检查室之间轻松移动。
Introduction: Strength measures with reduced variability and higher sensitivity could improve efficiency in clinical trials of amyotrophic lateral sclerosis (ALS). The Accurate Test of Limb Isometric Strength (ATLIS) was developed to precisely and conveniently measure force in 12 muscle groups. In this study we evaluate the reliability and validity of the ATLIS testing protocol. Methods: Twenty healthy adults and 10 patients with ALS were tested twice by the same or by different evaluators to determine test-retest and interrater reliability. Twenty healthy adults were examined using ATLIS and a wellvalidated strength testing protocol (TQNE) to assess criterionbased validity. Results: Mean absolute variation between tests was 8.6%, and intraclass correlation coefficients for each muscle group were high (range 0.82-0.99). The Pearson correlation coefficient of mean ATLIS and TQNE scores was 0.90. A subject survey demonstrated high user acceptance of ATLIS. Conclusions: ATLIS is convenient for patients and evaluators, produces precise strength measurements, and is easily moved between examining rooms.