Are Biochemical Markers of Bone Turnover Representative of Bone Histomorphometry in 370 Postmenopausal Women?
Are Biochemical Markers of Bone Turnover Representative of Bone Histomorphometry in 370 Postmenopausal Women?
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DOI：
10.1210/jc.2015-2957
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发表时间：
2015-12-01
影响因子：
5.8
通讯作者：
Chapurlat, Roland
中科院分区：
文献类型：
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作者：
Chavassieux, Pascale;Portero-Muzy, Nathalie;Chapurlat, Roland
背景：骨形成和吸收的水平可以通过髂骨活检的骨组织形态计量学在组织水平上进行评估。骨转换的全身生化标志物反映了整个骨骼水平的整体骨形成和吸收，但不能区分不同的骨骼区室。目的：我们的目的是研究形成和吸收的血清生化标志物与组织形态参数之间的相关性。设计：我们对先前的临床研究进行事后分析。背景：患者选自一般人群 患者：共有 371 名未经治疗的绝经后骨质疏松女性，年龄 50 至 84 岁，腰椎 T 评分 = 0.0001）。结论：骨转换标志物与髂松质骨中测量的骨转换参数显着但适度相关。髂嵴骨可能无法完美代表整个骨转换。
Context: The levels of bone formation and resorption can be assessed at the tissue level by bone histomorphometry on transiliac bone biopsies. Systemic biochemical markers of bone turnover reflect the overall bone formation and resorption at the level of the entire skeleton but cannot discriminate the different skeletal compartments.Objective: Our aim was to investigate the correlations between the serum biochemical markers of formation and resorption with histomorphometric parameters.Design: We performed post hoc analysis of a previous clinical study.Setting: Patients were selected from the general population.Patients: A total of 371 untreated postmenopausal osteoporotic women aged 50 to 84 years with a lumbar T-score = .0001).Conclusion: Bone turnover markers were significantly but modestly associated with bone turnover parameters measured in iliac cancellous bone. The iliac crest bone may not represent perfectly the whole bone turnover.