Changes in chemotherapy for pancreatic cancer.
Changes in chemotherapy for pancreatic cancer.
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胰腺癌化疗的变化。
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
T. Leung
中科院分区：
文献类型：
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作者：
T. Mok;T. Leung
目的：综述胰腺癌的全身化疗方案。资料来源：Medline和非Medline文献检索（1966-1999）。资料选择：关键词：胰腺癌;化疗;化疗药物;氟尿嘧啶;吉西他滨。资料提炼：回顾了II期研究、随机对照研究和临床前研究的报告。资料综合：只有不到20%的患者适合手术治疗，对于其余的患者，姑息性化疗的疗效甚微。联合氟尿嘧啶与亚叶酸或干扰素没有导致任何显着改善肿瘤反应或患者生存率。联合化疗早期令人鼓舞的结果尚未在随后的对照研究中得到证实。新方法包括免疫疗法和新型细胞毒性药物。单克隆抗体的体外研究显示出希望，但未能显示临床疗效。最近，吉西他滨已被证明在缓解疼痛和减少疾病相关症状方面比氟尿嘧啶更有效。结论：全身化疗对提高胰腺癌患者的生存时间一般无效。未来关于治疗的临床研究应侧重于基于吉西他滨的联合化疗或联合放疗。
OBJECTIVE: To review the systemic chemotherapy regimens for pancreatic cancer. DATA SOURCES: Medline and non-Medline literature search (1966-1999). STUDY SELECTION: The following key words were used: pancreatic carcinoma; chemotherapy; antineoplastic agent; fluorouracil; gemcitabine. DATA EXTRACTION: Reports of phase II studies, randomised controlled studies, and preclinical studies were reviewed. DATA SYNTHESIS: Less than 20% of patients are suitable candidates for surgery; for the remainder, palliative chemotherapy is of only marginal benefit. Combining fluorouracil with folinic acid or interferon has not led to any significant improvement in tumour response or the patient survival rate. The early encouraging results with combination chemotherapy have not been confirmed in subsequent controlled studies. New approaches include immunotherapy and novel cytotoxic drugs. In vitro studies of monoclonal antibodies have shown promise but have failed to show clinical efficacy. Recently, gemcitabine has been shown to be more effective than fluorouracil in delivering pain relief and reducing disease-related symptoms. CONCLUSION: Systemic chemotherapy is generally ineffective in increasing the survival time of patients with pancreatic cancer. Future clinical investigations concerning treatment should focus on gemcitabine-based combination chemotherapy or combined modality treatment with radiotherapy.
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氟尿嘧啶和重组干扰素 α-2a 在晚期结直肠癌患者中的 II 期试验：一项东部肿瘤合作组研究。
DOI：
10.1200/jco.1991.9.10.1806
发表时间：
1991
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Wadler,S;Lembersky,B;Atkins,M;Kirkwood,J;Petrelli,N
通讯作者：
Petrelli,N
影响因子：
45.3
作者：
CROWN, J;CASPER, ES;KELSEN, DP
通讯作者：
KELSEN, DP
影响因子：
45.3
作者：
KLAASSEN, DJ;MACINTYRE, JM;MOERTEL, CG
通讯作者：
MOERTEL, CG
局部不可切除的胰腺癌的治疗：联合疗法（化疗加放疗）与单独化疗的比较。
DOI：
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发表时间：
1988
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
通讯作者：
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