Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study.
Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study.
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DOI：
10.1371/journal.pone.0150712
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Korogi Y
中科院分区：
文献类型：
--
作者：
Ueda I;Kakeda S;Watanabe K;Yoshimura R;Kishi T;Abe O;Ide S;Moriya J;Katsuki A;Hori H;Iwata N;Nakamura J;Korogi Y
早期的研究表明，去甲肾上腺素转运体(Net)基因(SLC6A2)多态性与抑郁症的病因有关。最近发现SLC6A2基因外显子9的G1287A和启动子区域的T-182C两个单核苷酸多态与不同人群的MDD相关。我们研究了MDD患者SLC6A2的这两个基因多态性与脑体积的关系。我们获得了30名首发MDD患者和48名年龄和性别匹配的健康受试者(HS)的3D高分辨率T1加权图像。根据G1287A或T-182C等位基因的多态性将所有受试者分为4组。VBM分析检验了诊断、基因和基因-诊断交互作用的影响。左侧颞叶上皮质区对脑形态有诊断作用。T-182C和G1287A没有发现显著的基因效应。在左侧背外侧前额叶皮质发现显著的基因(G1287A)-诊断交互作用。在任何脑区均未观察到显著的基因(T-182C)-诊断交互作用。在MDD患者中，SLC6A2 G1287A基因的多态性似乎与背外侧前额叶皮质的体积有关。
Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients. We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects (HS). All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions. Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype (G1287A)–diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype (T-182C)–diagnosis interaction effects were observed in any brain region. In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.