Motor cortex stimulation for pain and movement disorders
Motor cortex stimulation for pain and movement disorders
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DOI：
10.1016/j.nurt.2007.11.004
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发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Shils, Jay L.
中科院分区：
文献类型：
--
作者：
Arle, Jeffrey E.;Shils, Jay L.
自20世纪90年代早期的最初报道以来，刺激皮层的Ml区域（MCS）已被用于治疗慢性难治性疼痛病症和各种运动障碍。Medline检索1991年至2007年的文献，发现512例使用MCS的病例。虽然其中大多数与疼痛治疗有关（422），但其中84例涉及运动障碍。最近，有几项研究专门研究了MCS治疗帕金森病（PD）。我们在这里报告了我们自己的几个病例，使用MCS治疗中风后和非中风后疼痛综合征和运动障碍（n = 8），PD（n = 4），ET（n = 2）和皮质基底变性（n = 1）。我们还涵盖了这一过程的基本历史和我们目前的研究使用计算建模，以进一步了解MCS的基本机制。
Since initial reports in the early 1990s, stimulation of the M I region of the cortex (MCS) has been used to treat chronic refractory pain conditions and a variety of movement disorders. A Medline search of literature between 1991 and 2007 revealed 512 cases using MCS. Although most of these relate to the treatment of pain (422), 84 of them involve movement disorders. More recently, several studies have specifically looked at treating Parkinson's disease (PD) with MCS. We report here several of our own cases using MCS to treat poststroke and non-poststroke pain syndromes and movement disorders (n = 8), PD (n = 4), ET (n = 2), and cortico-basal degeneration (n = 1). We also cover the essential history of this procedure and our current research using computational modeling to understand further the underlying mechanisms of MCS.