Now is it time to implement spacers in cervical cancer brachytherapy?

Now is it time to implement spacers in cervical cancer brachytherapy?
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DOI:
10.1093/jrr/rrac031
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发表时间:
2022-07-19
影响因子:
2
通讯作者:
--
中科院分区:
医学4区
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--
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尽管关于宫颈癌MRI引导近距离放射治疗的国际研究(EMBRACE-I)证明了无论T分期如何均具有良好的局部控制,但观察到高达14.6%的3-5级晚期放射相关毒性,这是不可接受的。虽然水凝胶间隔器在前列腺放疗中的疗效已得到证实,但其在宫颈癌近距离放射治疗中的实施速度相对较慢,尽管有几篇文章报道了其在宫颈癌近距离放射治疗中的疗效。作者认为,在宫颈癌近距离放射治疗和其他妇科恶性肿瘤的近距离放射治疗中使用间隔器将减少晚期放射相关毒性并改善患者的生活质量;因此,需要快速实施。
Although the international study on MRI-guided brachytherapy in cervical cancer (EMBRACE-I) demonstrated excellent local control regardless of the T stage, up to 14.6% of grade 3–5 late radiation-related toxicities were observed, which is unacceptable. While the efficacy of hydrogel spacers has been established in prostate radiotherapy, its implementation speed in cervical cancer brachytherapy is relatively slow, despite the fact that several articles have reported its efficacy in cervical cancer brachytherapy. The authors believe that using a spacer in cervical cancer brachytherapy and brachytherapy for other gynecologic malignancies will reduce late radiation-related toxicity and improve patients’ quality of life; therefore, its rapid implementation is required.
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