Facile synthesis of aryl- and alkyl-bis(trifluoromethylsulfonyl)methanes
Facile synthesis of aryl- and alkyl-bis(trifluoromethylsulfonyl)methanes
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DOI：
10.1246/bcsj.78.1401
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发表时间：
2005-08-15
影响因子：
4
通讯作者：
Yamamoto, H
中科院分区：
文献类型：
--
作者：
Hasegawa, A;Ishikawa, T;Yamamoto, H
以三氟甲烷亚磺酸钠和三氟甲磺酸酐为原料，合成了一系列芳基双（三氟甲磺酰基）甲烷（1）。此外，当1的芳基是五氟苯基时，发生芳基被烷基锂和烷氧基钠的亲核对位取代。该反应对设计新的Bronsted酸具有重要意义。
Various arylbis(trifluoromethylsulfonyl)methanes (1) have been synthesized by reacting the corresponding benzylic halides with sodium trifluoromethanesulfinate and then with triflic anhydride. In addition, when the aryl group of 1 is a pentafluorophenyl group, the nucleophilic para-substitution of the aryl group with alkyllithiums and sodium alkoxides occurs. This reaction is useful for the design of new Bronsted acids.