Immuno stimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis
Immuno stimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis
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DOI：
10.1016/s0378-8741(03)00226-5
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发表时间：
2003-10-01
影响因子：
5.4
通讯作者：
Satta, D
中科院分区：
文献类型：
--
作者：
Bendjeddou, D;Lalaoui, K;Satta, D
Anacyclus 除虫菊 (L.) Link 的热水多糖提取物。 （菊科）Citrullus colocynthis (L.) Schrad。 （葫芦科）和 Alpinia galanga (L.) Willd。 （姜科）在小鼠中测试了其免疫刺激活性。除虫菊和高良姜的组分对网状内皮系统（RES）显示出显着的刺激作用，并增加小鼠腹膜渗出细胞（PEC）和脾细胞的数量。在这种情况下，两个部分的最佳剂量分别为 50 和 25 mg/kg。另一方面，通过两项测试（体外和体内效果），除虫菊和高良姜的多糖提取物在体外显着增强小鼠脾细胞的增殖。对于除虫菊和高良姜而言，剂量为50和25mg/kg的体内效果结果表明，其刺激指数分别优于50和25μg/ml的体外效果。而西瓜提取物的免疫刺激活性则较弱且多变。 (C) 2003 年，爱思唯尔爱尔兰有限公司出版。
Hot water polysaccharide extracts of Anacyclus pyrethrum (L.) Link. (family Compositae) Citrullus colocynthis (L.) Schrad. (family Cucurbitaceae) and Alpinia galanga (L.) Willd. (family Zingiberaceae) were tested for their immunostimulating activity in mice. The fractions from Anacyclus pyrethrum and Alpinia galanga showed a marked stimulating effect on the reticulo-endothelial system (RES) and increased the number of peritoneal exudate cells (PEC), and spleen cells of mice. In this case, the optimum doses were 50 and 25 mg/kg for the two fractions, respectively. On the other hand, the polysaccharide extracts of both Anacyclus pyrethrum and Alpinia galanga markedly enhanced the proliferation of the murine spleen cells in vitro using two tests (in vitro and in vivo effect). The results of the in vivo effect at a doses of 50 and 25 mg/kg, showed a stimulation index better than obtained with the in vitro effect at 50 and 25 mug/ml for Anacyclus pyrethrum and Alpinia galanga, respectively. While the extract of Citrullus colocynthis showed much weaker and variable immunostimulating activity. (C) 2003 Published by Elsevier Ireland Ltd.