Triple Stimuli-Responsive Magnetic Hollow Porous Carbon-Based Nanodrug Delivery System for Magnetic Resonance Imaging-Guided Synergistic Photothermal/Chemotherapy of Cancer
Triple Stimuli-Responsive Magnetic Hollow Porous Carbon-Based Nanodrug Delivery System for Magnetic Resonance Imaging-Guided Synergistic Photothermal/Chemotherapy of Cancer
复制标题
用于磁共振成像引导的癌症协同光热/化疗的三重刺激响应磁空心多孔碳基纳米药物递送系统
DOI：
10.1021/acsami.8b07213
复制
发表时间：
2018-07-04
影响因子：
9.5
通讯作者：
Zhang, Jun
中科院分区：
文献类型：
--
作者：
Wu, Fan;Zhang, Ming;Zhang, Jun
抗癌药在血液循环中过早渗漏可能会损害免疫系统、正常细胞和组织。构建具有pH、谷胱甘肽和近红外三重响应特性的靶向纳米载体，可以有效避免抗癌药物在到达靶向位点之前的泄漏。本文成功制备了磁性中空多孔碳纳米颗粒（MHPCNs）作为纳米载体。聚γ -谷氨酸（Poly - gamma-glutamic acid）用于封住mhpcn的孔。利用碳和氧化铁（Fe3O4）纳米材料的光热转化特性进行光热治疗，以克服化疗产生的多药耐药。采用磁共振成像技术研究纳米颗粒的生物分布。体内实验证实了纳米颗粒在肿瘤部位的有效积累。同时，通过协同光热/化疗有效抑制肿瘤生长，副作用最小。
The premature leakage of anticancer drugs during blood circulation may the damage immune system, normal cells, and tissues. Constructing targeted nanocarriers with pH, glutathione, and NIR triple-responsive property can effectively avoid the leakage of anticancer drugs before they arrive at the targeted site. In this paper, magnetic hollow porous carbon nanoparticles (MHPCNs) were successfully fabricated as nanocarrier. Poly(gamma-glutamic acid) was used to cap the pores of MHPCNs. The photothermal conversion property of carbon and iron oxide (Fe3O4) nanomaterials was utilized to perform photothermal therapy to overcome multidrug-resistance produced by chemotherapy. The biodistribution of nanoparticles was investigated by magnetic resonance imaging. Experiments in vivo confirm the efficient accumulations of nanoparticles at tumor sites. Meanwhile, tumor growth was effectively inhibited via synergistic photothermal/chemotherapy with minimal side effects.