Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity:: Population-based and dietary intervention studies
Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity:: Population-based and dietary intervention studies
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DOI：
10.1210/jc.2007-1136
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发表时间：
2007-12-01
影响因子：
5.8
通讯作者：
Carlsson, Lena M. S.
中科院分区：
文献类型：
--
作者：
Gummesson, Anders;Jernas, Margareta;Carlsson, Lena M. S.
内容：细胞死亡诱导DNA片段化因子-α样效应子A（CIDEA）可能是通过调节代谢率治疗肥胖症的潜在靶点，这是基于CIDEA抑制啮齿动物棕色脂肪组织解偶联过程的发现。目的：我们的目的是研究CIDEA和人类基础代谢率之间的假定联系，并进一步阐明CIDEA在人类肥胖症中的作用。设计：我们在两项不同的人体研究中探索了CIDEA基因在脂肪组织中的表达：一项评估身体成分和代谢率的横断面和基于人群的研究（Molndal代谢研究，n = 92）;以及对接受极低热量饮食（VLCD）治疗的肥胖受试者进行的纵向干预研究结果：CIDEA基因主要在脂肪细胞中表达。脂肪组织中CIDEA基因表达与基础代谢率呈负相关，与身体成分、年龄和性别无关（P = 0.014）。VLCD诱导脂肪组织CIDEA表达增加（P < 0.0001），随后响应于再喂养而降低（P < 0.0001）。CIDEA基因表达降低与高体脂含量（P < 0.0001）和高胰岛素水平（P < 0.01）相关。与体重指数匹配的对照组相比，在代谢综合征患者中未观察到CIDEA表达失调。在一个单独的样品中的VLCD治疗的主题（n = 10），解偶联蛋白1表达减少饮食（P = 0.0026）和CIDEA表达呈负相关（P = 0.0014）。结论：研究结果是一致的概念，CIDEA在脂肪组织能量消耗中发挥作用。
Context: Cell death-inducing DNA fragmentation factor-alpha-like effector A(CIDEA) could be a potential target for the treatment of obesity via the modulation of metabolic rate, based on the findings that CIDEA inhibits the brown adipose tissue uncoupling process in rodents.Objectives: Our objects were to investigate the putative link between CIDEA and basal metabolic rate in humans and to elucidate further the role of CIDEA in human obesity.Design: We have explored CIDEA gene expression in adipose tissue in two different human studies: a cross-sectional and population-based study assessing body composition and metabolic rate (Molndal Metabolic study, n = 92); and a longitudinal intervention study of obese subjects treated with a very low calorie diet (VLCD) (VLCD study, n = 24).Results: The CIDEA gene was predominantly expressed in adipocytes as compared with other human tissues. CIDEA gene expression in adipose tissue was inversely associated with basal metabolic rate independently of body composition, age, and gender (P = 0.014). The VLCD induced an increase in adipose tissue CIDEA expression (P < 0.0001) with a subsequent decrease in response to refeeding (P < 0.0001). Reduced CIDEA gene expression was associated with a high body fat content (P < 0.0001) and high insulin levels (P < 0.01). No dysregulation of CIDEA expression was observed in individuals with the metabolic syndrome when compared with body mass index-matched controls. In a separate sample of VLCD-treated subjects (n = 10), uncoupling protein 1 expression was reduced during diet (P = 0.0026) and inversely associated with CIDEA expression (P = 0.0014).Conclusion: The findings are consistent with the concept that CIDEA plays a role in adipose tissue energy expenditure.