Subgroups in dementia of the Alzheimer type identified using positron emission tomography.
Subgroups in dementia of the Alzheimer type identified using positron emission tomography.
复制标题
使用正电子发射断层扫描识别阿尔茨海默型痴呆的亚组。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
S. Rapoport
中科院分区：
文献类型：
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作者：
C. Grady;J. Haxby;M. Schapiro;A. Gonzalez;A. Kumar;M. Ball;L. Heston;S. Rapoport
我们通过应用主成分分析来识别亚组，检查了33名阿尔茨海默型痴呆患者的脑葡萄糖代谢模式。确定了四个亚组：1例患者主要为顶颞叶低代谢（15例患者）; 1例患者为大脑边缘代谢缺陷（8例患者）; 1例患者为左半球新皮质异常（5例患者）; 1例患者为额叶和顶颞叶缺陷（5例患者）。不同的亚组之间的神经心理障碍和精神症状的患病率。这些代谢亚组不能根据痴呆的严重程度、病程或年龄来解释，但很可能与潜在的病理学有关，具有可变的区域分布。
We examined patterns of cerebral glucose metabolism in 33 patients with dementia of the Alzheimer type by applying principal component analysis to identify subgroups. Four subgroups were identified: one with predominant parietotemporal hypometabolism (15 patients); one with paralimbic metabolic deficits (8 patients); one with left hemisphere neocortical abnormality (5 patients); and one with frontal and parietotemporal deficit (5 patients). Differences among the subgroups were found in neuropsychological impairments and prevalence of psychiatric symptoms. These metabolic subgroups could not be explained on the basis of dementia severity, illness duration, or age, but were most likely related to an underlying pathology with a variable regional distribution.