The toxicological implications of the interaction of butylated hydroxytoluene with other antioxidants and phenolic chemicals.
The toxicological implications of the interaction of butylated hydroxytoluene with other antioxidants and phenolic chemicals.
复制标题
丁基羟基甲苯与其他抗氧化剂和酚类化学品相互作用的毒理学影响。
DOI：
10.1016/0278-6915(86)90307-8
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Trush
中科院分区：
文献类型：
--
作者：
D. Thompson;M. Trush
丁基羟基苯甲醚(BHA)可促进玻璃过氧化物酶催化的丁基羟基甲苯(BHT)与微粒体蛋白的共价结合，并促进BHT-二氢醌甲基的形成。丁香酚、对羟基苯甲酸甲酯、香草醛、愈创木酚、阿魏酸和其他几种常见于食品和化妆品中的酚类化合物也增强了BHT的代谢活性。BHA是被测试的最有效的化合物。包括人在内的各种动物的肺、膀胱、肾脏和小肠的微生物体也能以过氧化氢或花生四烯酸为底物支持BHA和BHT的这种相互作用。这些体外观察扩展到活体小鼠肺模型。皮下注射BHA显著提高了给予阈值以下剂量BHT的小鼠的肺/体重比。讨论了BHT与其他抗氧化剂和酚类化合物相互作用的毒理学意义，以及它们与人类风险的潜在相关性。
Butylated hydroxyanisole (BHA) enhanced both thein vitroperoxidase-catalysed covalent binding of butylated hydroxytoluene (BHT) to microsomal protein and the formation of BHT-quinone methide. Eugenol, methylparaben, vanillin, guaiacol, ferulic acid and several other phenolic compounds commonly used in food and cosmetic products also enhanced the metabolic activation of BHT. BHA was the most effective compound tested. Microsomes from lung, bladder, kidney medualla and small intestine of various animal species, including man, were also able to support this interaction of BHA and BHT using either hydrogen peroxide or arachidonic acid as the substrate. Thesein vitroobservations were extended to anin vivomouse lung model. Subcutaneous injections of BHA significantly enhanced the lung/body weight ratio of mice given intraperitoneal injections of subthreshold doses of BHT. The toxicological implications of the interactions of BHT with other antioxidants and phenolic chemicals and their potential relevance to human risk are discussed.