Familial transmission of depression and antisocial behavior symptoms: disentangling the contribution of inherited and environmental factors and testing the mediating role of parenting
Familial transmission of depression and antisocial behavior symptoms: disentangling the contribution of inherited and environmental factors and testing the mediating role of parenting
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DOI：
10.1017/s0033291710001753
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发表时间：
2011-06-01
影响因子：
6.9
通讯作者：
Thapar, A.
中科院分区：
文献类型：
--
作者：
Harold, G. T.;Rice, F.;Thapar, A.
背景。通过双胞胎和收养设计，已经广泛研究了遗传和环境对儿童精神病理学的影响。我们提供了一种新颖的方法，使用通过体外受精（IVF）受孕的父母和孩子的样本来检查遗传和环境对精神病理学代际传播的影响。方法。样本包括通过体外受精方法出生的孩子的家庭，他们对孩子是否与养育母亲和父亲有遗传相关或无关的问题各不相同（母亲有遗传相关，n = 434；母亲有遗传无关，n = 127；父亲有遗传相关，n = 403；父亲有遗传无关，n = 156）。使用标准化问卷，母亲和父亲分别报告了自己的精神病理学（抑郁、攻击性）、对孩子的养育行为（温暖、敌意）以及孩子的精神病理学（抑郁、攻击性）。使用交叉评估者方法，其中相反的父母报告孩子的症状（即父亲报告母子二人的症状，反之亦然）。结果。对于母子二人组，在遗传无关的二人组中观察到母亲抑郁和孩子抑郁之间存在直接关联，而在遗传相关的二人组中观察到通过母子敌意和温暖的完全中介路径。对于父子二人组，观察到遗传相关的父子二人组的直接途径和介导途径。对于攻击行为，父母攻击行为和儿童攻击行为之间的直接关联完全是由父母对孩子的敌意介导的，这表明父母对孩子的敌意作为传播风险机制的作用。结论。在遗传相关和遗传无关的父子和母子二人组中观察到了精神病理学代际传播背后的遗传和环境介导的差异模式。
Background. Genetic and environmental influences on child psychopathology have been studied extensively through twin and adoption designs. We offer a novel methodology to examine genetic and environmental influences on the intergenerational transmission of psychopathology using a sample of parents and children conceived through in vitro fertilization (IVF).Method. The sample included families with children born through IVF methods, who varied as to whether the child was genetically related or unrelated to the rearing mother and father (mother genetically related, n = 434; mother genetically unrelated, n = 127; father genetically related, n = 403; father genetically unrelated, n = 156). Using standardized questionnaires, mothers and fathers respectively reported on their own psychopathology (depression, aggression), their parenting behavior toward their child (warmth, hostility) and their child's psychopathology (depression, aggression). A cross-rater approach was used, where opposite parents reported on child symptoms (i.e. fathers reported on symptoms for the mother-child dyad, and vice versa).Results. For mother-child dyads, a direct association between mother depression and child depression was observed among genetically unrelated dyads, whereas a fully mediated path was observed among genetically related dyads through mother-to-child hostility and warmth. For father-child dyads, direct and mediated pathways were observed for genetically related father-child dyads. For aggression, the direct association between parent aggression and child aggression was fully mediated by parent-to-child hostility for both groups, indicating the role of parent-to-child hostility as a risk mechanism for transmission.Conclusions. A differential pattern of genetic and environmental mediation underlying the intergenerational transmission of psychopathology was observed among genetically related and genetically unrelated father-child and mother-child dyads.