Technetium-99m MDP Scintigraphy: An Insensitive Tool for the Detection of Bone Marrow Metastases
Technetium-99m MDP Scintigraphy: An Insensitive Tool for the Detection of Bone Marrow Metastases
复制标题
Technetium-99m MDP 闪烁扫描仪：检测骨髓转移的不敏感工具
作者：
K. Gulenchyn;W. Papoff
本文回顾性分析了79例肺癌或乳腺癌患者的骨髓穿刺和~（99）Tc-MDP骨显像结果。评估骨图像是否存在骨髓扩张模式，其通过弥漫性干骺端活动增加可见，特别是在膝关节、踝关节和肘部。发现这种模式是骨髓转移存在的不敏感标志物（敏感性15%）。特异性为86%。当弥漫性增加干骺端活动是目前的Tc-99 m MDP骨跨度在恶性疾病患者，骨髓转移的可能性应进行骨髓穿刺和活检。
Seventy-nine cases with known carcinoma of the lung or breast who underwent both bone marrow aspiration and Tc-99m MDP bone scintigraphy were reviewed. The bone images were assessed for the presence of the pattern of bone marrow expansion which is visualized by diffuse increased metaphyseal activity, particularly evident at the knees, ankles, and elbows. This pattern was found to be an insensitive marker for the presence of marrow metastases (sensitivity 15%). The specificity of the finding was 86%. When diffuse increased metaphyseal activity is present on a Tc-99m MDP bone span in a patient with malignant disease, the possibility of bone marrow metastases should be pursued by marrow aspiration and biopsy.