Representation of amino acid sequences as two-dimensional point patterns
Representation of amino acid sequences as two-dimensional point patterns
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DOI：
10.1002/elps.1150181504
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发表时间：
1997-12-01
期刊：
影响因子：
2.9
通讯作者：
Fleck, E
中科院分区：
文献类型：
--
作者：
Pleissner, KP;Wernisch, L;Fleck, E
描述了一种将氨基酸序列表示为二维点模式（2-D图）的算法。该算法是基于混沌博弈表示（CGR）的DNA序列，并扩展到氨基酸序列。2-D图描绘了蛋白质的氨基酸序列和氨基酸组成。蛋白质序列的变化，如氨基酸的插入、缺失和重复，其特征在于特定的几何性质和二维图中的变化。2-D图可以被认为是蛋白质的二维“指纹”。该算法的属性是由用户定义的氨基酸序列解释。作为一个例子，生成两个选定的心脏蛋白质的2-D图。这些蛋白质的序列从蛋白质序列数据库SWISS-PROT获得。
An algorithm for the representation of amino acid sequences as two-dimensional point patterns (2-D plot) is described. The algorithm is based on chaos game representation (CGR) for DNA sequences and was extended for amino acid sequences. The 2-D plot depicts the sequentiality of amino acids and the amino acid composition of a protein. Changes in a protein sequence as insertion, deletion and repeats of amino acids are characterized by specific geometrical properties and changes in the 2-D plots. The 2-D plot may be considered as a two-dimensional "fingerprint" of a protein. The properties of the algorithm are explained by user-defined amino acid sequences. As an example the 2-D plots of two selected heart proteins are generated. The sequences of these proteins are obtained from the protein sequence database SWISS-PROT.