Low Vitamin D Serum Concentration Is Associated With High Levels of Hepatitis B Virus Replication in Chronically Infected Patients
Low Vitamin D Serum Concentration Is Associated With High Levels of Hepatitis B Virus Replication in Chronically Infected Patients
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DOI：
10.1002/hep.26488
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发表时间：
2013-10-01
期刊：
影响因子：
13.5
通讯作者：
Lange, Christian M.
中科院分区：
文献类型：
--
作者：
Farnik, Harald;Bojunga, Joerg;Lange, Christian M.
维生素D是一种重要的免疫调节剂，在炎症和代谢性肝脏疾病（包括丙型肝炎病毒（HCV）感染）中发挥着新兴作用。相比之下，维生素D代谢和慢性B肝炎（CHB）之间的关系不太清楚。因此，我们对203例未经治疗的慢性B型肝炎病毒（HBV）感染患者的血清25（OH）D-3水平进行定量，并检测其与CH B临床参数的相关性。在203名患者中，69名（34%）、95名（47%）和39名（19%）患有严重维生素D缺乏症（25（OH）D-3
Vitamin D is an important immune modulator that plays an emerging role in inflammatory and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the relationship between vitamin D metabolism and chronic hepatitis B (CHB) is less well characterized. Therefore, we quantified 25(OH)D-3 serum levels in a cohort of 203 treatment-naive patients with chronic hepatitis B virus (HBV) infection and tested for their association with clinical parameters of CHB. Of 203 patients, 69 (34%), 95 (47%), and 39 (19%) had severe vitamin D deficiency (25(OH)D-3