Microhabitats within Venomous Cone Snails Contain Diverse Actinobacteria
Microhabitats within Venomous Cone Snails Contain Diverse Actinobacteria
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DOI：
10.1128/aem.01238-09
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发表时间：
2009-11-01
影响因子：
4.4
通讯作者：
Schmidt, Eric W.
中科院分区：
文献类型：
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作者：
Peraud, Olivier;Biggs, Jason S.;Schmidt, Eric W.
放线菌可以是多种生物体的共生体，包括植物和动物。一些放线菌通过产生小分子次级代谢产物使宿主受益。由此产生的共生关系往往在发展上是复杂的。研究了与三种锥形蜗牛相关的放线菌。锥形蜗牛是有毒的热带海洋腹足动物，因其产生肽类神经毒素而受到广泛研究，但尚未报道对这些生物体的微生物学研究。采用微栖息地方法，将每只蜗牛解剖的组织作为单独的样本处理，以便分别探索组织中的细菌。我们的结果揭示了一个多样化、新颖且高度可培养的锥蜗牛相关放线菌群落，其中一些分离株在神经学检测中显示出有希望的生物活性。这表明锥螺可能代表了一个尚未开发的新型放线菌库，对药物发现具有潜在意义。
Actinomycetes can be symbionts in diverse organisms, including both plants and animals. Some actinomycetes benefit their host by producing small molecule secondary metabolites; the resulting symbioses are often developmentally complex. Actinomycetes associated with three cone snails were studied. Cone snails are venomous tropical marine gastropods which have been extensively examined because of their production of peptide-based neurological toxins, but no microbiological studies have been reported on these organisms. A microhabitat approach was used in which dissected tissue from each snail was treated as an individual sample in order to explore bacteria in the tissues separately. Our results revealed a diverse, novel, and highly culturable cone snail-associated actinomycete community, with some isolates showing promising bioactivity in a neurological assay. This suggests that cone snails may represent an underexplored reservoir of novel actinomycetes of potential interest for drug discovery.