Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia.
Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia.
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DOI：
10.3390/ijms22052432
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发表时间：
2021-02-28
影响因子：
5.6
通讯作者：
Saito S
中科院分区：
文献类型：
--
作者：
Nakashima A;Shima T;Tsuda S;Aoki A;Kawaguchi M;Furuta A;Yasuda I;Yoneda S;Yamaki-Ushijima A;Cheng SB;Sharma S;Saito S
自噬体对聚集蛋白的选择性降解是自噬作用的一个重要方面。器官和细胞中的蛋白质聚集已被强调为多种疾病的原因，包括神经退行性疾病、心力衰竭和肾衰竭。聚集体可能对细胞存活造成危害。细胞表现出三种主要的机制，对聚集体的积累：蛋白质重折叠的分子伴侣的上调，减少蛋白质过载的翻译抑制，蛋白质降解的泛素-蛋白酶体和自噬-溶酶体系统。据报道，自噬相关基因的缺失有助于体内细胞内蛋白质聚集。在先兆子痫胎盘的聚集体中识别的一些蛋白质包括参与神经退行性疾病的那些蛋白质。由于聚集体来源于细胞内和细胞外，细胞外聚集体的特殊内吞作用也采用自噬机制。在这篇综述中，我们讨论了聚集吞噬和/或巨自噬的缺乏如何导致胎盘形成不良，导致先兆子痫或胎儿生长受限。
Aggrephagy is defined as the selective degradation of aggregated proteins by autophagosomes. Protein aggregation in organs and cells has been highlighted as a cause of multiple diseases, including neurodegenerative diseases, cardiac failure, and renal failure. Aggregates could pose a hazard for cell survival. Cells exhibit three main mechanisms against the accumulation of aggregates: protein refolding by upregulation of chaperones, reduction of protein overload by translational inhibition, and protein degradation by the ubiquitin–proteasome and autophagy–lysosome systems. Deletion of autophagy-related genes reportedly contributes to intracellular protein aggregation in vivo. Some proteins recognized in aggregates in preeclamptic placentas include those involved in neurodegenerative diseases. As aggregates are derived both intracellularly and extracellularly, special endocytosis for extracellular aggregates also employs the autophagy machinery. In this review, we discuss how the deficiency of aggrephagy and/or macroautophagy leads to poor placentation, resulting in preeclampsia or fetal growth restriction.
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影响因子：
64.5
作者：
Kawaguchi, Y;Kovacs, JJ;Yao, TP
通讯作者：
Yao, TP
Atg7 调节 p53 活性以调节代谢应激期间的细胞周期和存活
DOI：
10.1126/science.1218395
发表时间：
2012-04-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lee IH;Kawai Y;Fergusson MM;Rovira II;Bishop AJ;Motoyama N;Cao L;Finkel T
通讯作者：
Finkel T
影响因子：
64.8
作者：
Khaminets, Aliaksandr;Heinrich, Theresa;Dikic, Ivan
通讯作者：
Dikic, Ivan
DOI：
10.1016/j.preghy.2010.12.002
发表时间：
2011-01
影响因子：
2.2
作者：
Burton, Graham J.;Yung, Hong-Wa
通讯作者：
Yung, Hong-Wa
影响因子：
21.3
作者：
Komatsu, Masaaki;Kurokawa, Hirofumi;Yamamoto, Masayuki
通讯作者：
Yamamoto, Masayuki