Speckle tracking echocardiography could detect the difference of pressure overload-induced myocardial remodelling between young and adult rats
Speckle tracking echocardiography could detect the difference of pressure overload-induced myocardial remodelling between young and adult rats
复制标题
斑点追踪超声心动图可以检测年轻和成年大鼠压力超负荷引起的心肌重塑的差异
DOI：
10.1098/rsif.2019.0808
复制
发表时间：
2020-02-26
影响因子：
3.9
通讯作者：
Huo, Yunlong
中科院分区：
文献类型：
--
作者：
Niu, Pei;Li, Li;Huo, Yunlong
斑点追踪超声心动图（STE）的评估提供了有用的信息，局部和整体左心室（LV）功能。本研究的目的是探讨基于ST的应变分析是否可以检测压力超负荷诱导的心肌重构在年轻和成年大鼠之间的差异。在手术后对具有横向主动脉缩窄（TAC）的年轻和成年大鼠以及年龄匹配的假手术进行生理学、血流动力学和组织学测量。使用双因素方差分析来检测各种测量参数的统计学差异。压力超负荷使射血分数、短轴缩短率、dp/dtmax和|DP/dtmin|但在术后9周内，成年大鼠左室舒张末期（艾德）压较青年大鼠明显升高。压力超负荷也导致青年和成年大鼠心脏游离壁峰值应变和应变率的不同变化，但室间隔的变化相似。组织学分析证实了心肌重构的变化，包括心肌细胞的凋亡率和胶原面积比的增加，在成年大鼠左室肥厚的心脏与年轻时相比。压力超负荷在幼年和成年动物之间不同程度地改变了心肌成分。基于ST的应变分析可以检测到压力超负荷引起的年轻和成年大鼠心肌重构的细微差异。
The assessment by speckle tracking echocardiography (STE) provides useful information on regional and global left ventricular (LV) functions. The aim of the study is to investigate if STE-based strain analysis could detect the difference of pressure overload-induced myocardial remodelling between young and adult rats. Physiological, haemodynamic, histological measurements were performed post-operatively in young and adult rats with transverse aortic constriction (TAC) as well as the age-matched shams. Two-way ANOVA was used to detect the statistical difference of various measured parameters. Pressure overload decreased the ejection fraction, fractional shortening, dp/dtmax and |dp/dtmin|, but increased the LV end-diastolic (ED) pressure in adult rat hearts for nine weeks after TAC operation than those in young rat hearts. Pressure overload also resulted in different changes of peak strain and strain rate in the free wall, but similar changes in the interventricular septum of young and adult rat hearts. The changes in myocardial remodelling were confirmed by the histological analysis including the increased apoptosis rate of myocytes and collagen area ratio in the free wall of adult rat hearts of LV hypertrophy when compared with the young. Pressure overload alters myocardial components in different degrees between young and adult animals. STE-based strain analysis could detect the subtle difference of pressure overload-induced myocardial remodelling between young and adult rats.