Pulsatile and Steady-State Pressure Trends in Children: A Window into the Future?
Pulsatile and Steady-State Pressure Trends in Children: A Window into the Future?
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儿童的脉动和稳态压力趋势：通向未来的窗口？
DOI：
10.1159/000371620
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kovacikova,Gabriela
中科院分区：
文献类型：
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作者：
Zachariah,JustinP;Kovacikova,Gabriela
主动脉通过重塑来适应增加的身体尺寸的能力有限。儿童肥胖症的急剧增加可能会压垮这种内在的重塑程序，并导致主动脉功能异常。正如假设的那样，作为主动脉功能指标的脉压确实随着儿童肥胖的增加而急剧上升，而与此同时，作为小阻力动脉功能指标的平均动脉压却下降了。这些不同的大动脉与小动脉指数可能结合起来解释了全球肥胖流行期间儿童和成人收缩压的反直觉下降。支持这些对比趋势的病理生理机制尚不清楚。
The aorta has limited ability to accommodate increasing body size by remodeling. The dramatic rise in pediatric obesity threatens to overwhelm this intrinsic remodeling program and lead to abnormal aortic function. As hypothesized, pulse pressure, as an index of aortic function, has indeed risen dramatically in parallel with the rise of pediatric obesity, while at the same time mean arterial pressure, as an index of small resistance artery function, has fallen. These divergent large-artery-versus-small-artery indices may combine to explain the counterintuitive decrease in systolic blood pressure in children and adults during the global obesity pandemic. The pathophysiologic mechanisms underpinning these contrasting trends are not yet known.