The Role of Proline in Energy Metabolism
The Role of Proline in Energy Metabolism
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DOI：
10.1007/978-1-4615-9221-1_5
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
E. Bursell
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文献类型：
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作者：
E. Bursell
Amino acids have long been recognized to be prominent constituents of the hemolymph and tissue fluids of insects, accounting for more than 30% of the total osmotic activity in advanced orders (Sutcliffe, 1963). Details of the amino acid pattern have been elucidated for many species, and the results have been widely reviewed (Florkin, 1958; Wyatt, 1961; Chen, 1966; Schoffeniels and Gilles, 1970; Jeuniaux, 1971), to reveal a situation of bewildering, but seemingly controlled (Collett, 1976a), complexity. The only feature that stands out as a general, though by no means universal, characteristic of insect hemolymph is the predominance of proline and/or of glutamate and its amide glutamine (see also more recent investigations of Barrett, 1974; Nurmi and Birt, 1974; Bailey, 1975; Barrett and Friend, 1975; Collett, 1976b; de Kort and Kramer, 1976.) The early work of Winteringham with radioactively labeled substrates indicated a high rate of turnover in amino acid pools (Winteringham and Harrison, 1956; Winteringham, 1958) and suggested that hemolymph amino acids in general, and proline and glutamate in particular, could serve as important sources of substrate for the Krebs cycle (see also reviews by Sacktor, 1961, 1974). Support for this view was provided by later work, which showed a significant depletion of proline during activity in a number of
