Further evidence for shared genetic effects between psychotic bipolar disorder and p50 suppression: A combined twin and family study
Further evidence for shared genetic effects between psychotic bipolar disorder and p50 suppression: A combined twin and family study
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DOI：
10.1002/ajmg.b.30653
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发表时间：
2008-07-05
影响因子：
2.8
通讯作者：
Rijsdijk, Fruehling
中科院分区：
文献类型：
--
作者：
Hall, Mei-Hua;Schulze, Katja;Rijsdijk, Fruehling
据报道，精神病性双相情感障碍患者存在P50抑制缺陷。在我们先前关于双相情感障碍的双胞胎一致和不一致的报告中，我们发现双相情感障碍和P50感觉门控之间有显著的遗传重叠。然而，该研究的样本量相对较小。另一项研究，莫兹利双相家庭研究，报告称双相精神病患者未受影响的亲属的P50门控减弱。然而，遗传和环境的影响混淆了家庭研究，由于缺乏同卵（MZ）双胞胎对。本研究将双胞胎样本和家庭样本相结合，以提高统计功效和研究设计，目的是。(1)证实了精神病性双相情感障碍和P50抑制减弱之间的关联，以及（2）验证了双胞胎样本中报告的两个性状之间的遗传重叠。我们还评估了双相情感障碍和另一种抑制指数P50条件测试（C-T）振幅差之间的关系。本研究共纳入309例受试者，包括91对双胞胎、31个双相情感障碍家族和45名无关健康对照。统计分析基于结构方程模型。双相情感障碍与P50抑制率降低和C-T振幅差降低显著相关。共同的遗传因素是这些关联的主要来源。抑制损害是由于较大的，不良门控，T振幅反应。结果提供了进一步的证据表明，受损的P50 supplies是有前途的内表型精神病性双相情感障碍。P50抑制受损的非特异性可能反映了共享精神病易感基因的影响。(C)2008 Wiley-Liss，Inc.
P50 suppression deficit has been reported in patients with psychotic bipolar disorder. In our previous report on twin pairs concordant and discordant for bipolar disorder, we found significant genetic overlap between bipolar disorder and P50 sensory gating. However, the sample size in that study was relatively small. A separate study, the Maudsley Bipolar Family Study, reported diminished P50 gating in unaffected relatives of psychotic bipolar patients. However, genetic and environmental influences are confounded in family studies due to lack of monozygotic (MZ) twin pairs. The current study combines the twin sample and the family sample in order to improve statistical power and study design, with the aims of. (1) substantiating the association between psychotic bipolar disorder and diminished P50 suppression and (2) verifying the genetic overlap between the two traits reported in the twin sample. We also assessed the relationship between bipolar disorder and an alternative suppression index, the P50 Condition-Testing (C-T) amplitude difference. A total of 309 subjects was included in this study, comprising 91 twin pairs, 31 bipolar families, and 45 unrelated healthy controls. Statistical analyses were based on structural equation modeling. Bipolar disorder was significantly associated with a diminished P50 suppression ratio and decreased C-T amplitude difference. Shared genetic factors were the main source of these associations. Suppression impairment was due to larger, poorly gated, T amplitude responses. The results provide further evidence that impaired P50 suppressions are promising endophenotypes for psychotic bipolar disorder. The non-specificity of impaired P50 suppression may reflect the impact of shared psychosis susceptibility genes. (C) 2008 Wiley-Liss, Inc.