Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms
Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms
复制标题
DOI：
10.1038/sj.npp.1300558
复制
发表时间：
2004-11-01
影响因子：
7.6
通讯作者：
Piomelli, D
中科院分区：
文献类型：
--
作者：
Giuffrida, A;Leweke, FM;Piomelli, D
内源性大麻素是一种生物活性脂质家族，可激活大脑中的CB 1大麻素受体，并产生强烈的情感和认知效应。在这里，我们研究了内源性大麻素信号在精神病状态的作用，通过测量急性偏执型精神分裂症患者脑脊液（CSF）中内源性大麻素anandamide的水平。我们发现，CSF大麻素水平是8倍，在抗精神病药初治的首发偏执型精神分裂症（n=47）比健康对照组（n=84），痴呆患者（n=13）或情感障碍患者（n=22）。这种改变在用拮抗多巴胺D-2样受体的“典型”抗精神病药治疗的精神分裂症患者（n=37）中不存在，但在用优先拮抗5 HT（2A）受体的“非典型”抗精神病药治疗的精神分裂症患者（n=34）中不存在。在未用药的急性期精神分裂症患者中，脑脊液大麻素浓度与精神病性症状呈负相关（r（S）=-0.452，P =0.001）。结果表明，在急性偏执型精神分裂症的花生四烯酸胺海拔可能反映了一种补偿性适应疾病状态。
The endocannabinoids are a family of bioactive lipids that activate CB1 cannabinoid receptors in the brain and exert intense emotional and cognitive effects. Here, we have examined the role of endocannabinoid signaling in psychotic states by measuring levels of the endocannabinoid anandamide in cerebrospinal fluid (CSF) of acute paranoid-type schizophrenic patients. We found that CSF anandamide levels are eight-fold higher in anti psychotic-naive first-episode paranoid schizophrenics (n=47) than healthy controls (n=84), dementia patients (n=13) or affective disorder patients (n=22). Such an alteration is absent in schizophrenics treated with 'typical' antipsychotics (n=37), which antagonize dopamine D-2-like receptors, but not in those treated with 'atypical' antipsychotics (n=34), which preferentially antagonize 5HT(2A) receptors. Furthermore, we found that, in nonmedicated acute schizophrenics, CSF anandamide is negatively correlated with psychotic symptoms (r(S)=-0.452, P=0.001). The results suggest that anandamide elevation in acute paranoid schizophrenia may reflect a compensatory adaptation to the disease state.