Cardiac autonomic nerve stimulation in the treatment of heart failure.

Cardiac autonomic nerve stimulation in the treatment of heart failure.
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DOI:
10.1016/j.athoracsur.2012.12.060
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发表时间:
2013-07
影响因子:
4.6
通讯作者:
Fukamachi, Kiyotaka
Fukamachi, Kiyotaka
中科院分区:
医学2区
文献类型:
--
作者:
Kobayashi, Mariko;Massiello, Alex;Karimov, Jamshid H.;Van Wagoner, David R.;Fukamachi, Kiyotaka

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通过电刺激对心脏自主神经张力进行治疗性调节的研究已经取得了令人鼓舞的早期临床结果。迷走神经刺激降低了心力衰竭的发病率和猝死率,但治疗性迷走神经刺激受到低血压和心动过缓副作用的限制。在实验中实施的交感神经刺激可能会加剧交感神经支配的自主神经失衡。相反,同时刺激交感神经和副交感神经心脏神经增加心肌收缩力而不增加心率。本文综述了电刺激心脏自主神经系统治疗心力衰竭的现状。
Research on the therapeutic modulation of cardiac autonomic tone by electrical stimulation has yielded encouraging early clinical results. Vagus nerve stimulation has reduced the rates of morbidity and sudden death from heart failure, but therapeutic vagus nerve stimulation is limited by side effects of hypotension and bradycardia. Sympathetic nerve stimulation that has been implemented in the experiment may exacerbate the sympathetic-dominated autonomic imbalance. In contrast, concurrent stimulation of both sympathetic and parasympathetic cardiac nerves increases myocardial contractility without increasing heart rate. This review assesses the current state of electrical stimulation of the cardiac autonomic nervous system to treat heart failure.
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