Insulin resistance and hypertension in patients with type 1 diabetes
Insulin resistance and hypertension in patients with type 1 diabetes
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DOI：
10.1016/j.jdiacomp.2011.03.006
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发表时间：
2011-07-01
影响因子：
3
通讯作者：
Pedro-Botet, Juan
中科院分区：
文献类型：
--
作者：
Chillaron, Juan J.;Sales, Maria P.;Pedro-Botet, Juan
目的：本研究旨在了解1型糖尿病患者高血压患病率，并分析其与胰岛素抵抗等相关因素的关系。设计和方法：对291例1型免疫介导型糖尿病患者进行横断面研究，这些患者来自两个门诊内分泌科诊所。所有参与者均为白种人，18岁或以上，1型糖尿病患者病程超过6个月，已完成研究方案。高血压定义为血压>= 130/80 mmHg或使用抗高血压药物，当用于治疗微量或大量蛋白尿时，不包括血管紧张素转换酶抑制剂或血管紧张素II受体阻滞剂。结果：87例[29.9%(95%可信区间，CI): 24.6%-35.2%] 1型糖尿病患者存在高血压。与正常患者相比，高血压患者年龄较大，男性居多，体重指数和超重/肥胖患病率较高，糖尿病病程较长。通过估计葡萄糖处置率（eGDR）量化的胰岛素敏感性在高血压患者中低于正常血压患者(5.2 +/- 1.4 vs. 9.1 +/- 1.2 mg kg（-1) min(-1)）
Aim: The aims of this study were to determine the prevalence of hypertension in type 1 diabetes patients and to analyze its relationship with insulin resistance and other associated factors.Design and Methods: A cross-sectional study on 291 patients with type 1 immune-mediated diabetes managed at two outpatient endocrinology clinics was performed. All participants were Caucasian, 18 years or older with type 1 diabetes duration of more than 6 months, who had completed the study protocol. Hypertension was defined as blood pressure >= 130/80 mmHg or use of antihypertensive medication, excluding angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers when used as treatment for micro- or macroalbuminuria.Results: Hypertension was found in 87 [29.9% (95% confidence interval, or CI): 24.6%-35.2%] patients with type 1 diabetes. Hypertensive patients presented older age, male predominance, higher body mass index and overweight/obesity prevalence, and longer diabetes duration compared with normotensive patients. Insulin sensitivity quantified by estimated glucose disposal rate (eGDR) was lower in patients with hypertension compared with normotensives (5.2 +/- 1.4 vs. 9.1 +/- 1.2 mg kg(-1) min(-1), P