Rates of nonexudative and exudative age-related macular degeneration among Asian American ethnic groups.
Rates of nonexudative and exudative age-related macular degeneration among Asian American ethnic groups.
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DOI：
10.1167/iovs.11-7179
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发表时间：
2011-08
影响因子：
4.4
通讯作者：
J. Stein;B. Vanderbeek;Nidhi Talwar;B. Nan;D. Musch;D. Zacks
中科院分区：
文献类型：
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作者：
J. Stein;B. Vanderbeek;Nidhi Talwar;B. Nan;D. Musch;D. Zacks
目的确定不同亚裔美国人非渗出性和渗出性年龄相关性黄斑变性（AMD）的风险是否不同。方法：对来自美国大型管理式医疗网络的索赔数据进行审查，以确定2001年至2007年期间≥ 1次眼科护理访视的40岁及以上亚裔美国人。使用国际疾病分类（ICD-9 CM）计费代码识别非渗出性和渗出性AMD的入组者。计算非渗出性和渗出性AMD的发病率和患病率，并按亚洲种族分层。进行了考克斯回归分析，以确定不同亚洲种族人群发生非渗出性和渗出性AMD的相对风险，并对社会人口学因素以及眼部和医疗状况进行了调整。结果：在44,103名符合纳入标准的亚裔美国人中，2221名（5.04%）患有非渗出性AMD，217名（0.49%）患有渗出性AMD。与非西班牙裔白色美国人相比，华裔美国人（校正风险比[HR]，1.63; 95%置信区间[CI]，1.50-1.77）和巴基斯坦裔美国人（HR，1.97，95% CI，1.40-2.77）的非渗出性AMD风险显著增加。相比之下，日裔美国人非渗出性AMD的风险比非西班牙裔白色美国人低29%（HR，0.71; 95% CI，0.59-0.85）。与白色美国人相比，任何亚洲种族的渗出性AMD风险均无显著差异。亚裔美国人是美国增长第二快的种族群体。眼部护理提供者必须了解该群体中AMD的总体疾病负担，并了解不同亚洲种族的发病率可能存在很大差异。
PURPOSE To determine whether the risk for nonexudative and exudative age-related macular degeneration (AMD) varies for Americans of different Asian ethnicities. METHODS Claims data from a large national United States managed care network were reviewed to identify Asian Americans age 40 and older who had ≥ 1 eye care visits from 2001 to 2007. International Classification of Disease (ICD-9CM) billing codes were used to identify enrollees with nonexudative and exudative AMD. Incidence and prevalence rates were calculated for nonexudative and exudative AMD and were stratified by Asian ethnicity. Cox regression analyses were performed to determine the relative risk for developing nonexudative and exudative AMD for persons of different Asian ethnicities, with adjustment for sociodemographic factors and ocular and medical conditions. RESULTS Of the 44,103 Asian Americans who met the inclusion criteria, 2221 (5.04%) had nonexudative AMD and 217 (0.49%) had exudative AMD. Chinese Americans (adjusted hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.50-1.77) and Pakistani Americans (HR, 1.97, 95% CI, 1.40-2.77) had a significantly increased risk for nonexudative AMD compared with non-Hispanic white Americans. By contrast, Japanese Americans had a 29% decreased risk for nonexudative AMD compared with non-Hispanic white Americans (HR, 0.71; 95% CI, 0.59-0.85). There were no significant differences in risk for exudative AMD for any of the Asian ethnicities compared with white Americans. CONCLUSIONS Asian Americans are the second fastest growing racial group in the United States. Eye care providers must be aware of the overall disease burden of AMD within this group and appreciate how disease rates can vary substantially among different Asian ethnicities.