Effects of Very Low Nicotine Content Cigarettes on Smoking Behavior and Biomarkers of Exposure in Menthol and Non-menthol Smokers
Effects of Very Low Nicotine Content Cigarettes on Smoking Behavior and Biomarkers of Exposure in Menthol and Non-menthol Smokers
复制标题
DOI：
10.1093/ntr/ntz160
复制
发表时间：
2019-12-01
影响因子：
4.7
通讯作者：
Hatsukami, Dorothy K.
中科院分区：
文献类型：
--
作者：
Denlinger-Apte, Rachel L.;Kotlyar, Michael;Hatsukami, Dorothy K.
导读：由于在美国销售的卷烟中有30%被定性为薄荷烟，因此了解人们对薄荷醇的偏好如何影响尼古丁减少政策的影响是很重要的。方法：在最近的一项试验中，不寻求治疗的吸烟者被随机分配接受极低尼古丁香烟（VLNC； 0.4 mg尼古丁/g烟草）或正常尼古丁香烟（NNC； 15.5 mg/g烟草），为期20周。根据参与者的喜好，他们抽薄荷或不含薄荷的香烟。我们进行了多变量回归分析，以检验薄荷醇偏好是否会调节尼古丁含量对每日香烟（CPD）、呼吸一氧化碳（CO）、尿总尼古丁当量（TNE）、尿2-氰乙基巯基酸（CEMA）和戒断的影响。结果：在基线时，薄荷醇吸烟者（n = 346）报告吸烟的CPD较低（14.9比19.2），tne（52.8比71.6 nmol/mg）和CO（17.7比20.5 ppm）水平低于非薄荷醇吸烟者（n = 406; ps）
Introduction: Because 30% of cigarettes sold in the United States are characterized as menthol cigarettes, it is important to understand how menthol preference may affect the impact of a nicotine reduction policy.Methods: In a recent trial, non-treatment-seeking smokers were randomly assigned to receive very low nicotine cigarettes (VLNC; 0.4 mg nicotine/g tobacco) or normal nicotine cigarettes (NNC; 15.5 mg/g) for 20 weeks. On the basis of preference, participants received menthol or non-menthol cigarettes. We conducted multivariable regression analyses to examine whether menthol preference moderated the effects of nicotine content on cigarettes per day (CPD), breath carbon monoxide (CO), urinary total nicotine equivalents (TNE), urinary 2-cyanoethylmercapturic acid (CEMA), and abstinence.Results: At baseline, menthol smokers (n = 346) reported smoking fewer CPD (14.9 vs. 19.2) and had lowerTNE (52.8 vs. 71.6 nmol/mg) and CO (17.7 vs. 20.5 ppm) levels than non-menthol smokers (n = 406; ps