Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments
Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments
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DOI：
10.1016/s0306-4522(98)00583-1
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发表时间：
1999-03-01
期刊：
影响因子：
3.3
通讯作者：
Di Chiara, G
中科院分区：
文献类型：
--
作者：
Bassareo, V;Di Chiara, G
中脑隔核是起源于中脑腹侧被盖区的中脑边缘多巴胺神经元的主要靶点。(3)涉及通过药物和病变对多巴胺传递的实验操作以及对细胞外多巴胺浓度的体内监测的研究已经提供了证据，表明丘脑核的多巴胺传递在由常规（例如，食物，性）（22，23，29）和药物。（6，14）动机行为分为食欲（准备/预期）阶段和完成阶段，前者由旨在寻找和接近奖励本身的灵活反应模式组成，后者由固定反应模式组成（吃，喝，交配等）。最后确定利用生物资源的奖励（热量，代谢，遗传等）(13)虽然一些研究报告了与食欲和消费行为有关的丘脑核中多巴胺传递的刺激，但其他研究报告了与消费行为的关系。(10 16，20，28）因此，多巴胺在丘脑核中的传递与动机行为的特定阶段之间的精确关系存在争议。在地形学、组织化学和连接证据的基础上，延髓核被细分为两个室，即腹内侧的“壳”和背外侧的“核”。（1，8，9，11）这种异质性可能与目前关于脑桥核多巴胺在行为中的作用的争论有关。因此，人们可能会假设，根据多巴胺传递被监测的丘脑核的特定隔室，获得与激发行为的特定刺激的不同关系。为了验证这种可能性，我们通过微透析（4，27）监测了在食物激发的行为的食欲和消费阶段，丘脑核壳和核中多巴胺传递的变化。作为食物，我们利用了一种可口的零食（Fonzies），在我们实验室以前的研究中已经表明，它的消费会在丘脑核壳和内侧前额叶皮层中释放多巴胺。(2)不可预测的消费Fonzies优先刺激多巴胺传输的外壳相比，核心。食欲的食物刺激（穿孔Fonzies填充盒）相刺激多巴胺传输的核心，但不是在壳和敏感的多巴胺反应，喂养的核心，但抑制在壳。这些明确的差异之间的核壳和核心表明，阶段性多巴胺传输在每个隔室的核壳subserves动机行为的不同角色。(C)1999年IBRO。出版社：Elsevier Science Ltd
The nucleus accumbens septi is the major target of mesolimbic dopamine neurons originating in the ventral tegmental area of the mesencephalon.(3) Studies involving experimental manipulation of dopamine transmission by drugs and by lesions, as well as in vivo monitoring of extracellular dopamine concentrations, have provided evidence that the dopamine transmission of the nucleus accumbens plays an important role in behaviour motivated by conventional (e.g., food, sex)(22,23,29) and drug reinforcers.(6,14) Motivated behaviour is distinguished into an appetitive (preparatory/anticipatory) phase consisting of flexible response patterns intended to search and approach the reward itself, and a consummatory phase, consisting of fixed response patterns (eating, drinking, copulating, etc.) finalized to the utilization of the biological resources of the reward (caloric, metabolic, genetic, etc.)(13) While some studies reported a stimulation of dopamine transmission in the nucleus accumbens in relation to appetitive as well as consummatory behaviour,(7,19) other studies reported a relationship exclusively with consummatory behaviour.(10,16,20,28) Therefore, the precise relationship between dopamine transmission in the nucleus accumbens and specific phases of motivated behaviour is debated. On the basis of topographical, histochemical and connectional evidence, the nucleus accumbens has been subdivided into two compartments, medioventral "shell" and a laterodorsal "core".(1,8,9,11) This heterogeneity may be relevant to the current debate over the role of nucleus accumbens dopamine in behaviour. Thus, one might hypothesize that, depending on the specific compartment of the nucleus accumbens where dopamine transmission is monitored, a different relationship with specific stimuli which motivate behaviour is obtained. In order to verify this possibility we monitored by microdialysis(4,27) the changes in dopamine transmission in the nucleus accumbens shell and core during appetitive and consummatory phases of behaviour motivated by food. As food we utilized a palatable snack food (Fonzies) whose consumption has been shown in previous studies from our laboratory to release dopamine in the nucleus accumbens shell and in the medial prefrontal cortex.(2) Unpredicted consumption of Fonzies preferentially stimulated dopamine transmission in the shell as compared to the core. Appetitive food stimuli (perforated Fonzies-filled boxes) phasically stimulated dopamine transmission in the core but not in the shell and sensitized the dopamine response to feeding in the core but inhibited that in the shell. These clear-cut differences between nucleus accumbens shell and core suggest that phasic dopamine transmission in each compartment of the nucleus accumbens subserves different roles in motivated behaviour. (C) 1999 IBRO. Published by Elsevier Science Ltd.