Anti-Inflammatory Activities and Related Mechanism of Polysaccharides Isolated from Sargentodoxa cuneata
Anti-Inflammatory Activities and Related Mechanism of Polysaccharides Isolated from Sargentodoxa cuneata
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DOI：
10.1002/cbdv.201800343
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发表时间：
2018-11-01
影响因子：
2.9
通讯作者：
Li, Zhengrong
中科院分区：
文献类型：
--
作者：
Guo, Lanfang;Ma, Ruili;Li, Zhengrong
在中国，大红袍水煎剂用于治疗关节炎已有数百年的历史。本文中，从S.评价cuneata的体外和体内抗炎作用。PSC及其亚组分PSCA-1和PSCB-1通过下调诱导型一氧化氮合酶（iNOS）水平，显著抑制LPS诱导的RAW264.7细胞一氧化氮（NO）释放。PSC还能显著抑制角叉菜胶诱导的大鼠足跖肿胀，降低大鼠足跖、血清和肝脏中丙二醛（MDA）和前列腺素E2（PGE 2）的含量。此外，PSC还能提高大鼠血清和肝脏超氧化物歧化酶（SOD）的活性。结果表明，从S. cuneata（PSC）具有较强的抗炎活性，可能是抗关节炎的重要活性成分之一。
Sargentodoxa cuneata decoction has been used to treat arthritis in China for hundreds of years. Herein, the polysaccharide fraction (PSC) purified from S. cuneata was evaluated for its in vitro and in vivo anti-inflammatory effects. PSC and its sub-fractions PSCA-1 and PSCB-1 significantly suppressed nitric oxide (NO) release in LPS-induced RAW264.7 cells by down regulating the inducible nitric oxide synthase (iNOS) level. Furthermore, PSC markedly inhibited carrageenan induced rat hind paw edema, decreased in hind paw, serum and liver malondialdehyde (MDA) levels and prostaglandin E-2 (PGE(2)) levels. In addition, PSC increased superoxide dismutase (SOD) activity in serum and liver of the rats. These results revealed that the polysaccharide obtained from S. cuneata (PSC) possessed potent anti-inflammatory activity and may be one of the important bioactive constituents from the plant responsible for the anti-arthritis effect.