Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture
Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture
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DOI：
10.1016/j.archger.2010.02.002
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Tappero, Rosa
中科院分区：
文献类型：
--
作者：
Di Monaco, Marco;Vallero, Fulvia;Tappero, Rosa
身体组成的变化，包括肌肉和骨质的减少，伴随着衰老。我们的目的是评估髋部骨折妇女中肌肉减少症的患病率及其与骨质疏松症的关系。我们对340名妇女中的313名进行了双能X线吸收测定（DXA）扫描，20.9 ± 6.5（平均值± S。D.）髋关节骨折发生后30天。为了调整每个女性的平均瘦体重，我们将其除以身高的平方。313名女性中共有180名（58%）为肌肉减少症，而230名（74%）为肌肉减少症。在调整年龄和骨折与DXA扫描之间的间隔后，我们发现肌肉减少症与骨质疏松症之间存在显著相关性（p = 0.026）。对于肌肉减少症女性，骨质疏松症的校正比值比（OR）为1.80（95%CI = 1.07-3.02）。我们的数据显示，在大样本的髋部骨折妇女中，肌肉减少症的患病率很高，且与骨质疏松症有显著相关性。数据支持针对骨和肌肉组织的骨质疏松症和肌肉减少症的预防和治疗策略的研究方法。此外，考虑到骨骼脆弱的肌肉减少症女性比例较高，在估计肌肉减少症的经济负担时应考虑数据。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Changes in body composition, including a decrease in muscle and bone mass, accompany aging. Our aim was to assess the prevalence of sarcopenia and its association with osteoporosis in hip-fracture women. We performed a Dual-Energy X-Ray Absorptiometry (DXA) scan in 313 of 340 women, 20.9 +/- 6.5 (mean +/- S. D.) days after hip-fracture occurrence. To adjust appendicular lean mass for body size we divided it by height squared in each woman. A total of 180 of the 313 women (58%) were sarcopenic, whereas 230 (74%) were osteoporotic. After adjustment for age and interval between fracture and DXA scan we found a significant association between sarcopenia and osteoporosis (p = 0.026). For a sarcopenic woman the adjusted odds ratio (OR) for osteoporosis was 1.80 (95% CI = 1.07-3.02). Our data shows the high prevalence of sarcopenia and its significant association with osteoporosis in a large sample of hip-fracture women. Data supports a research approach on preventive and treatment strategies for osteoporosis and sarcopenia targeting both bone and muscle tissue. Furthermore, data should be considered when the economic burden of sarcopenia is estimated, given the high proportion of sarcopenic women with bone fragility. (C) 2010 Elsevier Ireland Ltd. All rights reserved.