Tempromandibular joint (TMJ) response to intra-articular dexamethasone injection following mechanical arthropathy: a histological study in rats
Tempromandibular joint (TMJ) response to intra-articular dexamethasone injection following mechanical arthropathy: a histological study in rats
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DOI：
10.1016/j.ijom.2004.05.004
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发表时间：
2005-05-01
影响因子：
2.4
通讯作者：
Bader, A
中科院分区：
文献类型：
--
作者：
El-Hakim, IE;Abdel-Hamid, IS;Bader, A
本研究的目的是评价和比较地塞米松关节内注射与腹腔注射对大鼠TMJ创伤诱导的滑膜炎的影响。通过连续10天手动打开大鼠的嘴10次来诱导强迫髁突过度活动。将大鼠随机分为三组（对照组中3只大鼠，两个实验组中24只大鼠）。（对照组）：诱导滑膜炎后不进行任何处理。II组：关节内注射地塞米松1.2mg/kg第三组：大鼠腹腔注射地塞米松1.2mg/kg在6周时处死对照大鼠，而在药物注射后1周和6周时处死组II和III中的大鼠，关节腔内注射地塞米松的大鼠髁状突头出现骨吸收，并具有活跃的骨吸收活性，但地塞米松仅给药一次。这可能是局部注射地塞米松的严重不良反应的警告信号。
The purpose of this study was to evaluate as well as to compare the effect of intra-articular versus intra-peritoneal injection of dexamethasone on synovitis induced by trauma to the rat's TMJ.Twenty-seven male Wister rats were included in the present study. Induced forced condylar hypermobility achieved through opening the rat's mouth manually 10 times for 10 consecutive days. Rats were randomized into three groups (3 rats in the control group, and 24 rats in both experimental groups).Group I (control group): Rats of this group were left without any treatment after induction of synovitis.Group II: Rats were injected with a single dose of 1.2 mg/kg dexamethasone intraarticularly (after 10 days).Group III: Rats were injected with a single intra-peritoneal injection of 1.2 mg/kg dexamethasone (after 10 days).Control rats were sacrificed at 6 weeks, while rats in Groups II and III were sacrificed at 1 and 6 weeks after drug injection, then joints were dissected and processed for histological study.The condylar head of the rats injected with intra-articular dexamethasone showed resorption with active osteoclastic activity, although the drug was given only once. This might be an alarming sign of the severe adverse effect(s) of the local injection of dexamethasone.