The metabolic basis of whole-organism RNA and phosphorus content
The metabolic basis of whole-organism RNA and phosphorus content
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DOI：
10.1073/pnas.0504756102
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发表时间：
2005-08-16
影响因子：
11.1
通讯作者：
Woods, HA
中科院分区：
文献类型：
--
作者：
Gillooly, JF;Allen, AP;Woods, HA
了解生物体中营养物质的储存、通量和周转对于定量生物区系对地球化学循环的贡献非常重要。在这里，我们提出了一个模型，预测富磷RNA和全身磷含量在真核生物的基础上的质量和温度依赖性的ATP生产的线粒体的存储。来自各种真核生物的数据支持该模型的两个主要预测。首先，全身RNA浓度与线粒体密度成比例，因此与体重成-1/4次方。第二，全身磷含量下降，随着真核单细胞中的体重增加，但在大型多细胞动物接近一个相对恒定的值，因为RNA中的磷的分数相对于其他池中的分数减少。模型的扩展表明，RNA相关磷通量的差异是由于代谢速率和RNA浓度的大小依赖性。因此，该模型在个体层面明确地将两种生物货币联系起来：ATIP形式的能量和磷形式的物质，这两者对生态系统的功能都至关重要。该模型提供了一个框架，连接个人的属性，在生态系统中的磷的存储和通量。
Understanding the storage, flux, and turnover of nutrients in organisms is important for quantifying contributions of biota to biogeochemical cycles. Here we present a model that predicts the storage of phosphorus-rich RNA and whole-body phosphorus content in eukaryotes based on the mass- and temperature-dependence of ATP production in mitochondria. Data from a broad assortment of eukaryotes support the model's two main predictions. First, whole-body RNA concentration is proportional to mitochondrial density and consequently scales with body mass to the -1/4 power. Second, whole-body phosphorus content declines with increasing body mass in eukaryotic unicells but approaches a relatively constant value in large multicellular animals because the fraction of phosphorus in RNA decreases relative to the fraction in other pools. Extension of the model shows that differences in the flux of RNA-associated phosphorus are due to the size dependencies of metabolic rate and RNA concentration. Thus, the model explicitly links two biological currencies at the individual level: energy in the form of ATIP and materials in the form of phosphorus, both of which are critical to the functioning of ecosystems. The model provides a framework for linking attributes of individuals to the storage and flux of phosphorus in ecosystems.