Temperament and response to the Trier Social Stress Test.
Temperament and response to the Trier Social Stress Test.
复制标题
气质和对特里尔社会压力测试的反应。
DOI：
10.1111/j.1600-0447.2006.00941.x
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发表时间：
2007
影响因子：
6.7
通讯作者：
Carpenter,LL
中科院分区：
文献类型：
--
作者：
Tyrka,AR;Wier,LM;Anderson,GM;Wilkinson,CW;Price,LH;Carpenter,LL
目的：人格特征行为抑制和神经质与心境和焦虑障碍有关，在一些研究中，与下丘脑-垂体-肾上腺（HPA）轴过度活跃有关。我们最近报道，在无精神疾病的健康成人中，低水平的新奇寻求与血浆皮质醇对地塞米松/促肾上腺皮质激素释放激素（Dex/CRH）试验的反应升高相关。本研究测试了气质和HPA轴功能之间的关联在同一组subjects使用标准化的心理社会神经内分泌stress test.Method：受试者完成诊断访谈，问卷调查，和特里尔社会压力测试（TSST）。结果：新奇寻求与血浆皮质醇浓度呈负相关，在基线和整个TSST，但不相关的促肾上腺皮质激素（ACTH）levels.Conclusion：本研究的结果扩展我们以前的发现在Dex/CRH测试的心理社会压力测试。未来的研究需要复制这些发现，并进一步阐明气质和个性如何与HPA功能相关。
Objective:The personality characteristics behavioural inhibition and neuroticism have been associated with mood and anxiety disorders and, in some studies, hypothalamic–pituitary–adrenal (HPA) axis hyperactivity. We recently reported that low levels of Novelty Seeking were associated with elevated plasma cortisol responses to the dexamethasone/corticotropin‐releasing hormone (Dex/CRH) test in healthy adults with no psychiatric disorder. The present study tested the association between temperament and HPA axis function in the same group of subjects using a standardized psychosocial neuroendocrine stress test.Method:Subjects completed diagnostic interviews, questionnaires, and the Trier Social Stress Test (TSST).Results:Novelty Seeking was inversely associated with plasma cortisol concentrations at baseline and throughout the TSST, but was not related to adrenocorticotropic hormone (ACTH) levels.Conclusion:Results of this study extend our previous finding in the Dex/CRH test to a psychosocial stress test. Future investigations are needed to replicate these findings and further elucidate how temperament and personality are linked to HPA function.